Clinical features and neuroimaging of PARK7‐linked parkinsonism

@article{Dekker2003ClinicalFA,
  title={Clinical features and neuroimaging of PARK7‐linked parkinsonism},
  author={Marieke C. J. Dekker and Vincenzo Bonifati and John Cornelis van Swieten and Nico Leenders and Robert‐Jan H. Galjaard and P J Snijders and Martin W. I. M. Horstink and Peter Heutink and Ben A. Oostra and Cornelia M. van Duijn},
  journal={Movement Disorders},
  year={2003},
  volume={18}
}
We recently reported linkage to chromosome 1p36 (the PARK7‐locus) in a family with early‐onset parkinsonism. Linkage to this locus has since been confirmed in an independent data set. We describe clinical and neuroimaging features of the 4 patients in the original PARK7‐linked kindred. Age at onset of parkinsonism varied from 27 to 40 years. Clinical progression was slow, and response to dopaminergic therapy good. The clinical spectrum ranged from mild hypokinesia and rigidity, to severe… Expand
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