Clinical features and management of two cases of encephalitis lethargica

  title={Clinical features and management of two cases of encephalitis lethargica},
  author={Stavia B. Blunt and Russell J. M. Lane and Nora Turjanski and George David Perkin},
  journal={Movement Disorders},
Two patients with presumed encephalitis lethargica are presented with clinical features suggestive of two forms of the disease described by Von Economo: One patient had a psychosis and a mute‐akinetic syndrome associated with myoclonus. The second patient presented with a psychosis and fever, developing severe dyskinesias involving the mouth, trunk and limbs, together with respiratory irregularities and presumed hypothalamic disturbance and disturbance of consciousness. In both cases, initial… 

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Contemporary encephalitis lethargica presenting with agitated catatonia, stereotypy, and dystonia‐parkinsonism

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Encephalitis lethargica syndrome: 20 new cases and evidence of basal ganglia autoimmunity.

Investigation found no evidence of viral encephalitis or other recognized causes of rapid-onset parkinsonism, and investigated the possibility that this phenotype could be a postinfectious autoimmune CNS disorder, and therefore similar to Sydenham's chorea.

Encephalitis lethargica (von Economo's encephalitis).

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Four previously healthy female children, aged between 3 and 8 years, who presented with encephalopathy and an extrapyramidal movement disorder are reported, suggesting that these patients represent an immune-mediated movement disorder and encephalopathic syndrome.

Immune mediated chorea encephalopathy syndrome in childhood

Four previously healthy female children, aged between 3 and 8 years, who presented with encephalopathy and an extrapyramidal movement disorder are reported, suggesting that these patients represent an immune‐mediated movement disorder and encephalopathic syndrome.




Postencephalitic parkinsonism most often appeared in the second and third decade of life, and contemporary clinicians of the time were struck by the number of children and young adults affected.

Encephalitis lethargica. A report of four recent cases.

Electroencephalographic, evoked potential and autopsy data suggest that involvement of the cerebral cortex is more extensive than has been generally recognized and in keeping with a viral aetiology.

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MRI of the brain disclosed a striking pattern of subcortical involvement by the inflammatory process in a patient with mycoplasma infection and clinical manifestations of encephalitis lethargica, corroborating the clinical picture.


The present case report illustrates the development of an acute, very severe transient parkinsonian syndrome immediately following an infection with a coxsackie virus type B2.

Response of patients with postencephalitic Parkinsonism to levodopa 1

Patients with postencephalitic Parkinsonism may respond as well as patients with Parkinson's disease to levodopa but they develop both favourable responses and side-effects at a lower dosage and require careful dosage adjustments and close surveillance.

Post-encephalitic Parkinsonism: current experience

Eight recent patients are discussed, six of whom presented in the last 20 years, that conform to the diagnosis of encephalitis lethargica and the clinical features by which the diagnosis may be made are defined so that a contemporary definition of this disorder may be attained.


For almost a century hearing loss and ear disease in the patient with cleft palate have been subjects of extensive investigation. The first to report this association was Alt,1 who in 1878 noted