Clinical features, diagnosis, and management of enterovirus 71
@article{Ooi2010ClinicalFD, title={Clinical features, diagnosis, and management of enterovirus 71}, author={Mong How Ooi and See Chang Wong and Penny Lewthwaite and Mary Jane Cardosa and Tom Solomon}, journal={The Lancet Neurology}, year={2010}, volume={9}, pages={1097-1105} }
658 Citations
Enteroviruses: Enterovirus 71
- Medicine, Biology
- 2014
Clinical predictors of the development of severe disease include high temperature and lethargy, and a lumbar puncture may reveal pleocytosis, and PCR applied to swabs from the throat or vesicle fluid, if available, is one of the most efficient.
Enterovirus 71 infection and neurological complications
- Medicine, BiologyKorean journal of pediatrics
- 2016
Treatment with intravenous immunoglobulin and milrinone are recommended in cases with severe neurological complications from EV71 infection, such as brainstem encephalitis, which can cause neurogenic pulmonary hemorrhage/edema leading to death.
Enterovirus-Associated Hand-Foot and Mouth Disease and Neurological Complications in Japan and the Rest of the World
- Medicine, BiologyInternational journal of molecular sciences
- 2019
Study in Vietnam suggest that myoclonus is a significant indicator of central nervous system (CNS) complications in EV-A71-associated HFMD cases, and surveillance and functional studies including development of antivirals and multivalent vaccines is critically important to reduce disease burden in pediatric populations.
[Neurological complications of infections with (novel) enteroviruses].
- Medicine, BiologyDer Nervenarzt
- 2018
A comprehensive supportive therapy for EV-D68 and EV-71 infections manifesting with neurological complications, namely rhombencephalitis and acute flaccid myelitis, is of major significance.
Clinico-radiological spectrum in enterovirus 71 infection involving the central nervous system in children
- Medicine, PsychologyJournal of Clinical Neuroscience
- 2014
Enterovirus 71 infection and vaccines
- Biology, MedicineClinical and experimental vaccine research
- 2017
Developing vaccines against EV71 would be the most effective approach to prevent EV71 outbreaks and to protect against fatal complications of HFMD, focusing on current scientific and clinical progress.
Massive pulmonary hemorrhage in enterovirus 71-infected hand, foot, and mouth disease
- Medicine, BiologyKorean journal of pediatrics
- 2015
A fatal case of EV71-associated HFMD with sudden-onset massive pulmonary hemorrhage and suspected encephalitis is reported, involving a 12-month-old boy admitted to a primary hospital with high fever and vesicular lesions of the mouth, hands, and feet.
Virology, epidemiology, pathogenesis, and control of enterovirus 71.
- Medicine, BiologyThe Lancet. Infectious diseases
- 2010
Direct Identification of Enteroviruses in Cerebrospinal Fluid of Patients with Suspected Meningitis by Nested PCR Amplification
- Medicine, BiologyViruses
- 2016
The developed RT-nested PCR amplification of the genomic region coding viral structural protein VP1 for direct identification of enteroviruses in clinical specimens and compared it with the existing analogs can be useful fordirect identification of Enterovirus in clinical material with the low virus loads such as CSF.
The epidemiology of non-polio enteroviruses: recent advances and outstanding questions
- Medicine, BiologyCurrent opinion in infectious diseases
- 2015
Improved molecular diagnostics and genetic sequence analysis are beginning to reveal the complex dynamics of individual serotypes and genotypes, and their contribution to recent outbreaks of enterovirus-associated disease, however, the biological mechanisms underlying their emergence and transmission dynamics remain elusive.
References
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Virology, epidemiology, pathogenesis, and control of enterovirus 71.
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- 2010
Neurologic complications in children with enterovirus 71 infection.
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- 1999
In the 1998 enterovirus 71 epidemic in Taiwan, the chief neurologic complication was rhombencephalitis, which had a fatality rate of 14 percent and the most common initial symptoms were myoclonic jerks, and MRI usually showed evidence of brainstem involvement.
Human enterovirus 71 disease in Sarawak, Malaysia: a prospective clinical, virological, and molecular epidemiological study.
- MedicineClinical infectious diseases : an official publication of the Infectious Diseases Society of America
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Genogroups of HEV-71 may differ with regard to the risk of causing central nervous system (CNS) complications and the association with family clusters.
Clinical spectrum of enterovirus 71 infection in children in southern Taiwan, with an emphasis on neurological complications.
- Medicine, PsychologyClinical infectious diseases : an official publication of the Infectious Diseases Society of America
- 1999
Brain stem encephalitis that progressed abruptly to neurogenic shock and NPE was indicative of poor prognosis in this epidemic and early aggressive treatment and close monitoring of the neurological signs are mandatory to improve the chance of survival.
Therapeutic efficacy of milrinone in the management of enterovirus 71‐induced pulmonary edema
- Medicine, BiologyPediatric pulmonology
- 2005
Results were associated with improvement in sympathetic regulation and decrease in IL‐13 production, and milrinone therapy may provide a useful therapeutic approach for this highly lethal disorder.
Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: roles of cytokines and cellular immune activation in patients with pulmonary edema.
- Medicine, BiologyThe Journal of infectious diseases
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An extensive peripheral and central nervous system inflammatory response with abnormal IL-10, IL-13, and IFN-gamma cytokine production and lymphocyte depletion appears to be responsible for the pathogenesis of EV71-associated PE.
Enterovirus 71 isolated from cases of epidemic poliomyelitis-like disease in Bulgaria
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Austrian strains of enterovirus 71 regularly caused paralysis in monkeys and morphological poliomyelitis-like lesions in their CNS, and paralysis and myositis with Zenker necrosis in newborn white mice, cotton rats, Syrian hamsters, and 3-week-old cotton rats.
MR Imaging Findings of Enteroviral Encephalomyelitis: An Outbreak in Taiwan
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Brain stem and cervical spinal cord involvement are characteristic findings of enteroviral encephalomyelitis in patients diagnosed with enterovirus infection in Taiwan.
Outbreak of severe neurologic involvement associated with Enterovirus 71 infection.
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- 1999