Clinical features, diagnosis, and management of enterovirus 71

@article{Ooi2010ClinicalFD,
  title={Clinical features, diagnosis, and management of enterovirus 71},
  author={Mong How Ooi and See Chang Wong and Penny Lewthwaite and Mary Jane Cardosa and Tom Solomon},
  journal={The Lancet Neurology},
  year={2010},
  volume={9},
  pages={1097-1105}
}
Although poliomyelitis has been mostly eradicated worldwide, large outbreaks of the related enterovirus 71 have been seen in Asia-Pacific countries in the past 10 years. This virus mostly affects children, manifesting as hand, foot, and mouth disease, aseptic meningitis, poliomyelitis-like acute flaccid paralysis, brainstem encephalitis, and other severe systemic disorders, including especially pulmonary oedema and cardiorespiratory collapse. Clinical predictors of severe disease include high… 
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TLDR
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TLDR
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[Neurological complications of infections with (novel) enteroviruses].
TLDR
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TLDR
Although most patients presenting with neurologic manifestations of enterovirus 71 infection had characteristic clinical features together with typical MRI findings, the clinical features were not necessarily consistent with MRI findings.
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TLDR
Developing vaccines against EV71 would be the most effective approach to prevent EV71 outbreaks and to protect against fatal complications of HFMD, focusing on current scientific and clinical progress.
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TLDR
A fatal case of EV71-associated HFMD with sudden-onset massive pulmonary hemorrhage and suspected encephalitis is reported, involving a 12-month-old boy admitted to a primary hospital with high fever and vesicular lesions of the mouth, hands, and feet.
Virology, epidemiology, pathogenesis, and control of enterovirus 71.
TLDR
Enterovirus 71 is a major public health issue across the Asia-Pacific region and beyond, with new outbreaks occurring across Asia in regular cycles, and virus gene subgroups seem to differ in clinical epidemiological properties.
Direct Identification of Enteroviruses in Cerebrospinal Fluid of Patients with Suspected Meningitis by Nested PCR Amplification
TLDR
The developed RT-nested PCR amplification of the genomic region coding viral structural protein VP1 for direct identification of enteroviruses in clinical specimens and compared it with the existing analogs can be useful fordirect identification of Enterovirus in clinical material with the low virus loads such as CSF.
The epidemiology of non-polio enteroviruses: recent advances and outstanding questions
TLDR
Improved molecular diagnostics and genetic sequence analysis are beginning to reveal the complex dynamics of individual serotypes and genotypes, and their contribution to recent outbreaks of enterovirus-associated disease, however, the biological mechanisms underlying their emergence and transmission dynamics remain elusive.
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