Clinical experience with aurora kinase inhibitors: a review.

@article{Boss2009ClinicalEW,
  title={Clinical experience with aurora kinase inhibitors: a review.},
  author={David S. Boss and Jos H. Beijnen and Jan H. M. Schellens},
  journal={The oncologist},
  year={2009},
  volume={14 8},
  pages={
          780-93
        }
}
The aurora kinase family of serine/threonine kinases comprises three members, designated auroras A, B, and C. Auroras A and B are essential components of the mitotic pathway, ensuring proper chromosome assembly, formation of the mitotic spindle, and cytokinesis. The role of aurora C is less clear. Overexpression of aurora A and B has been observed in several tumor types, and has been linked with a poor prognosis of cancer patients. Several small molecules targeting aurora kinases A and B or… CONTINUE READING

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