Clinical ex vivo lung perfusion--pushing the limits.

@article{Aigner2012ClinicalEV,
  title={Clinical ex vivo lung perfusion--pushing the limits.},
  author={Clemens Aigner and Abdelhak Slama and Konrad Hoetzenecker and Axel Scheed and Bernhard Urbanek and W. William Schmid and Franz Joseph Nierscher and Gyoergy Lang and Walter Klepetko},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2012},
  volume={12 7},
  pages={
          1839-47
        }
}
Ex vivo lung perfusion (EVLP) provides the ability to evaluate donor lungs before transplantation. Yet, limited prospective clinical data exist with regard to its potential to recondition unacceptable donor lungs. This paper summarizes the results of a prospective study of lung transplantation using only initially unacceptable donor lungs, which were improved by EVLP for 2-4 h. From March 2010-June 2011, 13 lungs were evaluated ex vivo. Median donor PaO(2) at FiO(2) 1.0/PEEP5 was 216 mmHg… CONTINUE READING
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