Clinical evidence on the effects of saffron (Crocus sativus L.) on cardiovascular risk factors: A systematic review meta‐analysis

@article{Pourmasoumi2019ClinicalEO,
  title={Clinical evidence on the effects of saffron (Crocus sativus L.) on cardiovascular risk factors: A systematic review meta‐analysis},
  author={Makan Pourmasoumi and Amir Hadi and Ameneh Najafgholizadeh and Marzieh Kafeshani and Amirhossein Sahebkar},
  journal={Pharmacological Research},
  year={2019},
  volume={139},
  pages={348–359}
}
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The Effect of Saffron Consumption on Liver Function: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials
TLDR
Saffron supplementation could not improve liver function tests including AST, ALT, and ALP among the adult population, and further clinical trials with larger sample size, longer duration, and higher doses of saffron should be conducted exclusively among patients with liver dysfunction.
The cardiovascular‐protective properties of saffron and its potential pharmaceutical applications: A critical appraisal of the literature
TLDR
Current clinical trials have shown mostly weak effects of saffron and its constituents on cardiovascular risk factors: Modest lowering of fasting blood glucose, without significant reduction of HbA1c in type 2 diabetic patients, moderate/controversial hypolipidemic effects, and negligible hypotensive effect.
Effect of saffron supplementation on oxidative stress parameters: A systematic review and meta‐analysis of randomized placebo‐controlled trials
TLDR
Saffron intake was shown to significantly impact MDA and TAC, indicating its beneficial properties in improving OS in unhealthy patients, however, additional RCTs are required to evaluate the effect on other OS parameters.
The therapeutic potential of Crocus sativus Linn.: A comprehensive narrative review of clinical trials.
TLDR
The present results can provide important insights into the potential of saffron in preventing and treating different disorders, with a special focus on the underlying cellular and molecular mechanisms.
The Effect of Green Coffee Bean Extract on Cardiovascular Risk Factors: A Systematic Review and Meta-analysis.
TLDR
The present study suggests that green coffee bean extract consumption can improve total cholesterol, triglycerides, body weight, blood pressure, and fasting plasma glucose.
Effect of saffron (Crocus sativus L.) on lipid profile, glycemic indices and antioxidant status among overweight/obese prediabetic individuals: A double-blinded, randomized controlled trial.
Impact of Crocus sativus L. on Metabolic Profile in Patients with Diabetes Mellitus or Metabolic Syndrome: A Systematic Review
TLDR
According to the available limited evidence, saffron may have a favorable effect on FBG and many of the studies in the reviewed literature are of poor quality, and more research is needed in this direction.
The effect of saffron supplementation on blood glucose and lipid profile: A systematic review and meta-analysis of randomized controlled trials.
Does Turmeric/curcumin Supplementation Change Anthropometric Indices in Patients with Non-alcoholic Fatty Liver Disease? A Systematic Review and Meta-analysis of Randomized Controlled Trials
TLDR
Meta-analysis showed that turmeric/curcumin supplementation had no significant effect on body weight, BMI and WC in patients with NAFLD, and further studies with large-scale are needed to find out possible anti-obesity effects.
The effect of crocin supplementation on lipid concentrations and fasting blood glucose: A systematic review and meta-analysis and meta-regression of randomized controlled trials.
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References

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TLDR
The present study indicated that the dose of about 100 mg crocin of saffron was well tolerated and has no complication for 6 weeks of oral administration, however, the dosage used in this study had no effect on metabolic syndrome.
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Although crocin supplements increased the serum cholesteryl ester transfer protein in patients with metabolic syndrome, this change was not significant between treatment and placebo groups.
Effect of cinnamon, cardamom, saffron and ginger consumption on blood pressure and a marker of endothelial function in patients with type 2 diabetes mellitus: A randomized controlled clinical trial
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Although administration of these herbal medicines as supplementary remedies could affect BP and sICAM-1 concentrations, there was no significant difference between the plants in terms of influencing anthropometric measures, BP and endothelial function.
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