Clinical evidence on the effects of saffron (Crocus sativus L.) on cardiovascular risk factors: A systematic review meta‐analysis

@article{Pourmasoumi2019ClinicalEO,
  title={Clinical evidence on the effects of saffron (Crocus sativus L.) on cardiovascular risk factors: A systematic review meta‐analysis},
  author={Makan Pourmasoumi and Amir Hadi and Ameneh Najafgholizadeh and Marzieh Kafeshani and Amirhossein Sahebkar},
  journal={Pharmacological Research},
  year={2019},
  volume={139},
  pages={348–359}
}

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References

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TLDR
The present study indicated that the dose of about 100 mg crocin of saffron was well tolerated and has no complication for 6 weeks of oral administration, however, the dosage used in this study had no effect on metabolic syndrome.
Effect of purslane on blood lipids and glucose: A systematic review and meta‐analysis of randomized controlled trials
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It is suggested that the purslane might be effective on the improvement of blood lipid and glucose levels and further robust studies with sufficient durations and dosages of supplementation are needed to confirm these results.
The effect of saffron (Crocus sativus L.) hydroalcoholic extract on metabolic control in type 2 diabetes mellitus: A triple-blinded randomized clinical trial
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Saffron hydroalcoholic extract may improve blood glucose control by reducing FBS in T2D patients, however, saffron extract has no significant effect on other aspects of diabetic control in diabetic patients.
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The current human clinical evidence supporting saffron supplementation as a treatment for a range of pathologies and the underlying science supporting its use are reviewed.
Saffron and crocin improved appetite, dietary intakes and body composition in patients with coronary artery disease
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The results of present study regarding anti-obesity feature of SAE and crocin in patients with CAD was promising, however the SAE was better in appetite suppressing, dietary intake and central obesity reduction.
Effect of crocin, a carotenoid from saffron, on plasma cholesteryl ester transfer protein and lipid profile in subjects with metabolic syndrome: A double blind randomized clinical trial
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Although crocin supplements increased the serum cholesteryl ester transfer protein in patients with metabolic syndrome, this change was not significant between treatment and placebo groups.
Effect of cinnamon, cardamom, saffron and ginger consumption on blood pressure and a marker of endothelial function in patients with type 2 diabetes mellitus: A randomized controlled clinical trial
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Although administration of these herbal medicines as supplementary remedies could affect BP and sICAM-1 concentrations, there was no significant difference between the plants in terms of influencing anthropometric measures, BP and endothelial function.
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