Clinical evidence of genomic imprinting in Tourette's syndrome.

  title={Clinical evidence of genomic imprinting in Tourette's syndrome.},
  author={D G Lichter and Lisa A. Jackson and M. D. Pinhas Schachter},
  volume={45 5},
Recent genetic studies of Tourette's syndrome (TS) have suggested a sex-specific expression of TS behaviors but not a sex-associated difference in their transmission. In a retrospective study designed to assess the influence of gender of the affected parent on childhood TS phenotype, we compared unmedicated TS subjects with patrilineal (n = 25) or matrilineal (n = 25) inheritance of TS, as determined by family history methodology, with respect to demographic variables, temporal profile of tic… CONTINUE READING


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