Clinical evidence of distinct subgroups of astrocytic tumors defined by comparative genomic hybridization.

@article{Nishizaki2000ClinicalEO,
  title={Clinical evidence of distinct subgroups of astrocytic tumors defined by comparative genomic hybridization.},
  author={Takafumi Nishizaki and Hisashi Kubota and Kei Harada and Haruo Ito and Mikio Suzuki and Kohsuke Sasaki},
  journal={Human pathology},
  year={2000},
  volume={31 5},
  pages={608-14}
}
In astrocytic tumors, the relationship between genetic pathways and patients' prognoses has not been fully investigated. In our studies of astrocytic tumors using comparative genomic hybridization, the presence of 8q gain was mutually exclusive of 7p gain or amplification. In this study, 45 cases of astrocytic tumor were divided into 3 groups: those with 7p gain, cases with 8q gain, or those with neither; and their clinical course, p53, and epidermal growth factor receptor (EGFR) expressions… CONTINUE READING