Clinical evaluation of the determination of plasma concentrations of darunavir, etravirine, raltegravir and ritonavir in dried blood spot samples.

@article{Heine2011ClinicalEO,
  title={Clinical evaluation of the determination of plasma concentrations of darunavir, etravirine, raltegravir and ritonavir in dried blood spot samples.},
  author={Rob Ter Heine and Jan Willem Mulder and Eric van Gorp and Jiri F. P. Wagenaar and Jos H. Beijnen and Alwin D. R. Huitema},
  journal={Bioanalysis},
  year={2011},
  volume={3 10},
  pages={1093-7}
}
BACKGROUND Measurement of drug levels in plasma is currently the gold standard for pharmacological studies. However, venous sampling is not feasible in some populations (e.g., neonates) or may be difficult in certain situations, such as nonhospital-based settings. Dried blood spots (DBS) can be obtained by a simple fingerprick and the subsequent collection… CONTINUE READING