Clinical evaluation of systemic and local immune responses in cancer: time for integration

  title={Clinical evaluation of systemic and local immune responses in cancer: time for integration},
  author={Dmitriy W. Gutkin and Michael R. Shurin},
  journal={Cancer Immunology, Immunotherapy},
The immune system has a dual role in cancer development and progression. On the one hand, it can eradicate emerging malignant cells, but on the other hand, it can actively promote growth of malignant cells, their invasive capacities and their ability to metastasize. Immune cells with predominantly anti-tumor functionality include cells of the innate immune system, such as natural killer cells, and cells of adaptive immunity, such as conventional dendritic cells and cytotoxic T lymphocytes… CONTINUE READING


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