Clinical evaluation of efficacy, safety and tolerability of cysteamine 5% cream in comparison with modified Kligman’s formula in subjects with epidermal melasma: A randomized, double‐blind clinical trial study

@article{Karrabi2020ClinicalEO,
  title={Clinical evaluation of efficacy, safety and tolerability of cysteamine 5\% cream in comparison with modified Kligman’s formula in subjects with epidermal melasma: A randomized, double‐blind clinical trial study},
  author={Maryam Karrabi and Jennifer David and Mohammad Sahebkar},
  journal={Skin Research and Technology},
  year={2020},
  volume={27},
  pages={24 - 31}
}
Kligman’s formula (KF) remains to date the dermatologists’ treatment of choice for melasma. This study was aimed at the evaluation of the effectiveness of Modified Kligman’s formula (MKF) in comparison with cysteamine 5% cream on the severity of epidermal melasma. 
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Melasma is a difficult‐to‐treat hyperpigmentary disorder. While cysteamine is a known potent depigmenting agent, its efficacy in treating melasma has not been tested.
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