Clinical evaluation of bone turnover by serum osteocalcin measurements in a hospital setting.

@article{Slovik1984ClinicalEO,
  title={Clinical evaluation of bone turnover by serum osteocalcin measurements in a hospital setting.},
  author={D. Slovik and C. Gundberg and R. Neer and J. Lian},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1984},
  volume={59 2},
  pages={
          228-30
        }
}
Serum levels of osteocalcin, the major noncollagenous bone protein, are elevated in patients with certain metabolic bone diseases, but the effects of other illnesses on serum osteocalcin levels are not known. We measured serum osteocalcin concentrations in 250 patients in a rehabilitation hospital who suffered from various illnesses. Mean serum osteocalcin levels were elevated in patients with 1) recent hip fracture who required open reduction and pin insertion (mean +/- SE, 19.0 +/- 3.2 ng/ml… Expand
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Serum osteocalcin holds promise as a useful marker of subacute changes in bone metabolism, particularly in children with renal failure and children with various forms of rickets. Expand
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Serum BGP determination cannot help to differentiate between paraneoplastic hypercalcemia and hyperCalcemia due to metastatic bone lysis; moreover, the findings suggest great variability of the bone formation rate in tumor‐associated hypercalCEmia, whether bone metastases are present or not. Expand
Serum osteocalcin concentrations in Paget's disease of bone.
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Evidence of impaired cartilage/bone turnover in patients with active ankylosing spondylitis.
TLDR
Bone metabolism in patients with ankylosing spondylitis is characterised by normal bone formation and enhanced cartilage/bone degradation, suggesting that impaired bone turnover is pronounced in active disease. Expand
spondylitis . in patients with active ankylosing Evidence of impaired cartilage / bone turnover
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Serum bone Gla protein: a marker of bone turnover in hyperthyroidism.
TLDR
It is suggested that BGP is a sensitive marker of bone metabolism alterations during hyperthyroidism that correlated significantly with serum T3 and T4 concentrations and did not correlate with circulating thyroid hormone levels. Expand
Metabolic bone assessment in patients with inflammatory bowel disease.
TLDR
The results suggest that bone turnover in inflammatory bowel disease is characterized by low bone formation in the presence of normal levels of calcium-regulating hormones. Expand
Osteocalcin and bone remodelling in Paget's disease of bone, primary hyperparathyroidism, hypercalcaemia of malignancy and involutional osteoporosis.
We have measured classic markers of bone turnover, serum alkaline phosphatase (sAP), urinary hydroxyproline/creatinine ratio (uOH-Prol/creatinine) and osteocalcin (sBGP), in two bone disordersExpand
Serum osteocalcin in Paget's disease of bone: basal concentrations and response to bisphosphonate treatment.
TLDR
It appears that the functions of osteocalcin and AP as well as their initial expression by the osteoblasts are different and that this difference may be important for the quality of bone formed in Paget's disease. Expand
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Urinary γ-Carboxyglutamic Acid and Serum Osteocalcin as Bone Markers: Studies in Osteoporosis and Paget’s Disease
Osteocalcin is a major bone matrix protein with high affinity for hydroxyapatite. This property is conferred by several residues of the calcium-binding amino acid γ-carboxyglutamate (Gla), whichExpand
Serum osteocalcin in the treatment of inherited rickets with 1,25-dihydroxyvitamin D3.
TLDR
Serum osteocalcin increases after 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] therapy in both ARVDD and XLH, and is significantly greater than values at 1 week (P less than 0.05). Expand
Assessment of bone turnover in postmenopausal osteoporosis by measurement of serum bone Gla-protein.
TLDR
The data suggest that overall bone turnover is increased in patients with postmenopausal osteoporosis and do not support the concept that an absolute decrease in bone formation is the major cause of the bone loss. Expand
Measurements of γ-carboxyglutamate and circulating osteocalcin in normal children and adults
Abstract We have measured serum osteocalcin ∗∗ by radioimmunoassay, and urinary γ-carboxyglutamic acid (Gla) by Dowex-1 chromatography in healthy adults and children. Circulating osteocalcin is6.8 ±Expand
Increase in serum bone gamma-carboxyglutamic acid protein with aging in women. Implications for the mechanism of age-related bone loss.
TLDR
Overall bone turnover increases in women with aging and, especially considering the concomitant decrease in skeletal mass, do not support the view that age-related bone loss results primarily from decreased bone formation. Expand
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TLDR
Plasma BGP was increased in patients with Paget's disease of bone, bone metastases, primary hyperparathyroidism, renal osteodystrophy, and osteopenia and it was observed that patients with liver disease had normal plasma BGP despite increased plasma AP, a reflection of the lack of specificity of AP measurements for bone disease. Expand
Concentrations of osteocalcin and phosphoprotein as a function of mineral content and age in cortical bone.
TLDR
A significant difference was found between the concentrations of Gla and Ser(P) with respect to the calcium content of the tissue, which may reflect the fact that the two classes of proteins have different biological functions and are concentrated in the tissue by different physical chemical mechanisms. Expand
Effect of renal function on plasma levels of bone Gla-protein.
TLDR
For normal subjects and patients with mild to moderate renal failure, plasma elevations of BGP reflect increased bone turnover rather than decreased renal filtration. Expand
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TLDR
The hypothesis that the role of y-carboxyglutamic acid in BGP is to enable the protein to bind strongly to hydroxyapatite and, by this association, accumulate in bone is supported. Expand
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TLDR
Four patients with hyperparathyroidism and osteitis fibrosa were studied before and after removal of a parathyroid adenoma, a period of transition from a predominance of bone collagen resorption to one of relatively increased bone collagen synthesis. Expand
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