Clinical evaluation of a new lipid-based delivery system for intravenous administration of amphotericin B

  title={Clinical evaluation of a new lipid-based delivery system for intravenous administration of amphotericin B},
  author={Denis Caillot and Pascal Chavanet and Olivier Casasnovas and {\'E}ric Solary and Gerardo Zanetta and Marielle Buisson and Oded Wagner and Bernadette Cuisenier and Alain Bonnin and P. Camerlynck and Henri Portier and Harold Guy},
  journal={European Journal of Clinical Microbiology and Infectious Diseases},
In a retrospective study a new lipid-based delivery system for administration of amphotericin B was evaluated in 26 treatment courses in 22 patients. Amphotericin B was given by infusion diluted in either the lipid solution (1 mg/kg/d; 13 courses) or dextrose (0.92 mg/kg/d; 13 courses). No differences were noted in the serum pharmacokinetics. Fever or rigors were observed in 6 of 13 courses in the conventional amphotericin B group versus none in the lipid amphotericin B group (p=0.007). Four of… CONTINUE READING


Publications referenced by this paper.
Showing 1-10 of 14 references

An emulsion formulation of amphotericin B improves the therapeutic index when treating systemic routine eandidiasis

  • R Kirsh, R Goidstein, +5 authors G Poste
  • Journal of Infectious Diseases
  • 1988

Liposome - eneapsulated amphoteriein B : a promising new treatment for disseminated fungal infections

  • J WiebeV, MW DeGregorio
  • Reviews of Infectious Diseases
  • 1988

Amphotericin B ( AMB )

  • A Kucers, N MckBennett
  • The use of antibiotics . A comprehensive review…
  • 1987

Amphotericin B (AMB). In: Heinemann W (ed): The use of antibiotics. A comprehensive review with clinical emphasis

  • A Kucers, N Mck Bennett
  • 1987
1 Excerpt

Induction of prostaglandin synthesis as the mechanism responsible for chills and fever produced by infusing am - photeriein B

  • F GigUotti, JL Shenep, L Loll, D Thornton
  • Journal of Infectious Diseases
  • 1987

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