Clinical evaluation in healthy adults of a hepatitis B vaccine made by recombinant DNA.

@article{Scolnick1984ClinicalEI,
  title={Clinical evaluation in healthy adults of a hepatitis B vaccine made by recombinant DNA.},
  author={Edward M. Scolnick and A A Mclean and David J. West and W. McAleer and William J. Miller and Eugene B. Buynak},
  journal={JAMA},
  year={1984},
  volume={251 21},
  pages={2812-5}
}
A vaccine formulated from hepatitis B surface antigen (HBsAg) produced by a recombinant strain of the yeast Saccharomyces cerevisiae was administered to two groups of human volunteers composed of 37 healthy, low-risk adults. Each subject received a 10-micrograms dose of HBsAg at 0, 1, and 6 months. By one month, 27% to 40% of the vaccinees had antibody to HBsAg, and by three months 80% to 100% were antibody positive. Large boosts in titer followed the third dose at six months. The antibody… CONTINUE READING

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