Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?
@article{Russo2004ClinicalED, title={Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?}, author={Ethan B. Russo}, journal={Neuro endocrinology letters}, year={2004}, volume={25 1-2}, pages={ 31-9 } }
OBJECTIVES
This study examines the concept of clinical endocannabinoid deficiency (CECD), and the prospect that it could underlie the pathophysiology of migraine, fibromyalgia, irritable bowel syndrome, and other functional conditions alleviated by clinical cannabis.
METHODS
Available literature was reviewed, and literature searches pursued via the National Library of Medicine database and other resources.
RESULTS
Migraine has numerous relationships to endocannabinoid function. Anandamide… Expand
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References
SHOWING 1-10 OF 125 REFERENCES
Cannabinoids for gastrointestinal diseases: potential therapeutic applications
- Chemistry, Medicine
- Expert opinion on investigational drugs
- 2003
- 139
Negative modultors of excitatory amino acids in episodic and chronic migraine: preventing and reverting chronic migraine. Special lecture 7th INWIN Congress.
- Medicine
- International journal of clinical pharmacology research
- 1998
- 10
Fibromyalgia and headache. Failure of serotonergic analgesia and N-methyl-D-aspartate-mediated neuronal plasticity: their common clues.
- Medicine
- Cephalalgia : an international journal of headache
- 1998
- 41
Fibromyalgia and migraine, two faces of the same mechanism. Serotonin as the common clue for pathogenesis and therapy.
- Medicine, Biology
- Advances in experimental medicine and biology
- 1996
- 67
Evaluation of drug treatment in irritable bowel syndrome.
- Medicine
- British journal of clinical pharmacology
- 2003
- 65