Clinical efficacy of potassium canreonate-canrenone in sinus rhythm restoration among patients with atrial fibrillation - a protocol of a pilot, randomized, double -blind, placebo-controlled study (CANREN-AF trial)

@article{Dbrowski2020ClinicalEO,
  title={Clinical efficacy of potassium canreonate-canrenone in sinus rhythm restoration among patients with atrial fibrillation - a protocol of a pilot, randomized, double -blind, placebo-controlled study (CANREN-AF trial)},
  author={R. Dąbrowski and Paweł Syska and J. Mączyńska and M. Farkowski and Stefan Sawicki and A. Kubaszek-Kornatowska and P. Michałek and I. Kowalik and H. Szwed and T. Hryniewiecki},
  journal={Trials},
  year={2020},
  volume={21}
}
Background Atrial fibrillation (AF) is the most frequent cardiac arrhythmia which increases the risk of thromboembolic complications and impairs quality of life. An important part of a therapeutic approach for AF is sinus rhythm restoration. Antiarrhythmic agents used in pharmacological cardioversion have limited efficacy and potential risk of proarrhythmia. Simultaneously, underlying conditions of AF should be treated (e.g. electrolyte imbalance, increased blood pressure, neurohormonal… Expand
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