Clinical efficacy of oral-transdermal clonidine combinations during the perioperative period.

@article{Segal1991ClinicalEO,
  title={Clinical efficacy of oral-transdermal clonidine combinations during the perioperative period.},
  author={Israel Segal and D R Jarvis and Steven R. Duncan and Paul F. White and Mervyn M Maze},
  journal={Anesthesiology},
  year={1991},
  volume={74 2},
  pages={220-5}
}
In an attempt to maintain stable levels of an alpha 2-adrenergic agonist throughout the perioperative period, two different oral-transdermal clonidine dosage regimens were administered according to a randomized, double-blind, placebo-controlled study in patients undergoing abdominal surgery. We determined the clinical efficacy of a high- and a low-dose clonidine regimen on sedation, hemodynamic parameters, anesthesia, and analgesia. The low-dose clonidine group of patients (n = 14) received a 7… CONTINUE READING
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