[Clinical efficacy of mouse nerve growth factor in treatment of occupational hand-arm vibration disease].

Abstract

OBJECTIVE To investigate the efficacy of mouse nerve growth factor (mNGF) in treating occupational hand-arm vibration disease (HAVD). METHODS Sixty-four patients with HAVD were equally and randomly divided into treatment group and control group. The control group was given Salvia miltiorrhiza Bunge and deproteinized extract of calf blood to improve circulation, and also given methylcobalamin tablets and vitamin B6 for neurotrophic treatment. In addition to the above treatments for the control group, the treatment group was also given 30 µg/d mNGF by intramuscular injection for two courses (4 weeks for each course) with a 15-day interval. RESULTS Both the treatment group and the control group showed significant improvements in clinical symptoms and signs (hand numbness and pain, and reduced senses of touch, pain, and vibration), cold water loading test (CWLT), and electroneuromyography (ENMG) after treatments (P < 0.05). And the treatment group had significantly more improvements than the control group (P < 0.05). CONCLUSION mNGF can significantly improve hand numbness and pain, reduced senses of touch, pain, and vibration, CWLT, and ENMG, so it has better clinical effect and safety in treating HAVD. Early diagnosis and treatment can improve the outcome of patients with HAVD.

Cite this paper

@article{Fan2014ClinicalEO, title={[Clinical efficacy of mouse nerve growth factor in treatment of occupational hand-arm vibration disease].}, author={Chunyue Fan and Yanyan Wang and Ying Zhang and Li Lang and Xiaofeng Deng and Ying - Sheng Cheng}, journal={Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases}, year={2014}, volume={32 12}, pages={924-7} }