Clinical efficacy assessment in photodamaged skin of 0.5% and 1.0% idebenone

  title={Clinical efficacy assessment in photodamaged skin of 0.5\% and 1.0\% idebenone},
  author={David H. McDaniel and Birgit A. Neudecker and Joseph C DiNardo and Jordan A Lewis and Howard I Maibach},
  journal={Journal of Cosmetic Dermatology},
Idebenone is an antioxidant lower molecular weight analogue of coenzyme Q10. Previously, idebenone was shown to be a very effective antioxidant in its ability to protect against cell damage from oxidative stress in a variety of biochemical, cell biological, and in vivo methods, including its ability to suppress sunburn cell (SBC) formation in living skin. However, no clinical studies have been previously conducted to establish the efficacy of idebenone in a topical skincare formulation for the… 

Idebenone: Novel Strategies to Improve Its Systemic and Local Efficacy

Different approaches investigated to overcome IDE drawbacks, such as IDE incorporation into different types of delivery systems (liposomes, cyclodextrins, microemulsions, self-micro-emulsifying drug delivery systems, lipid-based nanoparticles, polymeric nanoparticles) and IDE chemical modification are focused on.

Topical delivery of Idebenone using nanostructured lipid carriers: evaluations of sun-protection and anti-oxidant effects

The objective of present study was to develop nanostructured lipid carriers (NLC) for topical delivery of antioxidant drug and evaluation of its sun protection efficacy. In the present study attempts

Solid Lipid Nanoparticles Loading Idebenone Ester with Pyroglutamic Acid: In Vitro Antioxidant Activity and In Vivo Topical Efficacy

Results suggest that the investigated approach could be a promising strategy to obtain topical formulations with increased hydrating effects after topical application in human volunteers from gel vehicles of IDEPCA SLN in comparison to IDE SLN.

In Vitro Skin Permeation of Idebenone from Lipid Nanoparticles Containing Chemical Penetration Enhancers

The results suggest that the use of suitable PE as LNPs components could be regarded as a promising strategy to improve drug targeting to the skin.

Chemical and technological delivery systems for idebenone: a review of literature production

The different forms of delivery can help increase Idebenone solubility, stability and biochemical activity, and further studies will be developed in order to improve the controlled release and targeting of idebenone.

Oral and Systemic Photoprotection

Broad-spectrum sunscreens are particularly useful to inhibit epidermal gene modifications like mutations on p53 gene, generation of thymine dimers, and induction of apoptosis or to minimize enzymatic damage to the dermal matrix.

Nanostructured Lipid Carriers Improve Skin Permeation and Chemical Stability of Idebenone

NLCs containing IDB have significant potential use for skin care as an alternative topical formulation and the abilities of NLCs to improve the chemical stability of IDB and enhance the skin permeation are much better than NE and oil solution.

The effect of dietary intake of coenzyme Q10 on skin parameters and condition: Results of a randomised, placebo‐controlled, double‐blind study

Investigation of the effects of 12 weeks of daily supplementation with 50 and 150 mg of CoQ10 on skin parameters and condition determined significantly reduced wrinkles and microrelief lines, and improved skin smoothness, while Supplementation with Co Q10 did not significantly affect skin hydration and dermis thickness.

Facile Solvent-Free Preparation of Antioxidant Idebenone-Loaded Nanoparticles for Efficient Wound Healing

IB@NPs showed excellent biocompatibility, inhibited oxidative damage to mouse NIH-3T3 fibroblasts, and reduced intracellular ROS generation according to an in vitro DPPH antioxidant assay, and significantly promoted wound healing in vitro, as demonstrated by scratch assays.



Idebenone: a new antioxidant – Part I. Relative assessment of oxidative stress protection capacity compared to commonly known antioxidants

A multistep in vitro process utilizing a variety of biochemical and cell biological methods combined with in vivo studies was designed to compare the oxidative stress protective capacity of commonly used antioxidants, and the higher the score, the more effective the overall oxidative stress protection capacity of the antioxidant became.

Double‐Blind, Half‐Face Study Comparing Topical Vitamin C and Vehicle for Rejuvenation of Photodamage

  • R. FitzpatrickE. Rostan
  • Medicine
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • 2002
This formulation of vitamin C results in clinically visible and statistically significant improvement in wrinkling when used topically for 12 weeks, and correlates with biopsy evidence of new collagen formation.

Use of topical ascorbic acid and its effects on photodamaged skin topography.

A 3-month daily regimen of topical ascorbic acid provided objective and subjective improvement in photodamaged facial skin using an objective, computer-assisted image analysis of skin surface topography and subjective clinical, photographic, and patient self-appraisal questionnaires.

Coenzyme Q10, a cutaneous antioxidant and energizer

This work has investigated whether topical application of CoQ10 has the beneficial effect of preventing photoaging.

Anti-aging benefits of topical formulation containing Coenzyme Q10: Results of 2 clinical studies

  • Cosmet Dermatol
  • 2002

Figure 6 Immunofluorescence biopsy. (a) Before and after staining for MMP-1; (b) before and after staining for IL-6; (c) before and after staining for IL-1b

    Genetic research unlocks secrets of effective skincare

      Idebenone: the ultimate antiaging drug. Offshore Pharmacy

        Genetic research unlocks secrets of effective

        • 1997

        Genetic research unlocks secrets of effective skincare. Aesthetic Buyers Guide