Clinical efficacy and pharmacokinetics of montelukast in dyspeptic children with duodenal eosinophilia.

@article{Friesen2004ClinicalEA,
  title={Clinical efficacy and pharmacokinetics of montelukast in dyspeptic children with duodenal eosinophilia.},
  author={Craig Friesen and Gregory L. Kearns and L. A. de Andr{\'e} and Mark Neustrom and Charles C. Roberts and Susan M Abdel-Rahman},
  journal={Journal of pediatric gastroenterology and nutrition},
  year={2004},
  volume={38 3},
  pages={343-51}
}
BACKGROUND Montelukast, a competitive cysteinyl leucotriene-1 receptor antagonist, reduces airway eosinophilia in asthmatics. We evaluated the effect of this drug in children with eosinophilic duodenitis, defined histologically as duodenal mucosa with peak eosinophil count of more than 10 eosinophils/hpf. METHODS Forty children and adolescents (6-18 yr) with dyspepsia and duodenal eosinophilia were enrolled in a double blind, randomized, placebo-controlled, cross-over study of monteleukast… CONTINUE READING

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