Clinical efficacies of shampoos containing ciclopirox olamine (1.5%) and ketoconazole (2.0%) in the treatment of seborrhoeic dermatitis

@article{Ratnavel2007ClinicalEO,
  title={Clinical efficacies of shampoos containing ciclopirox olamine (1.5\%) and ketoconazole (2.0\%) in the treatment of seborrhoeic dermatitis},
  author={R. C. Ratnavel and R A Squire and G. C. Boorman},
  journal={Journal of Dermatological Treatment},
  year={2007},
  volume={18},
  pages={88 - 96}
}
Background: Ciclopirox olamine (CPO) is a broad‐spectrum antifungal with anti‐inflammatory properties effective against the yeast implicated in seborrhoeic dermatitis, Malassezia spp. This study compared 1.5% CPO shampoo with 2.0% ketoconazole shampoo and placebo in scalp seborrhoeic dermatitis. Methods: A randomized, double‐blind, 4‐week treatment period was preceded by a 2‐week run‐in period and followed by a 2‐week run‐out period. A total of 350 patients (150 CPO, 150 ketoconazole, 50… 

Treatment of seborrhoeic dermatitis of the scalp with a topical solution of urea, lactic acid, and propylene glycol (K301): results of two double‐blind, randomised, placebo‐controlled studies

The K301 was well tolerated and associated with clinically meaningful improvements in seborrhoeic dermatitis endpoints and showed significant improvements in symptomatic investigator and patient assessments for K301 over placebo after 4’weeks.

To Compare the Efficacy of Different Therapeutic Agents in Treatment of Seborrheic Dermatitis

It can be inferred from the results that topical ketoconazole still remains the most effective and preferred antifungal drug for the treatment of SD and steroid sparing immunemodulator topical tacrolimus had a statistical advantage over conventional topical steroid application.

Lipohydroxy acid containing shampoo in the treatment of scalp seborrheic dermatitis

Clinical studies evaluating both the efficacy, the tolerance, the cosmetic properties and the benefit in patient’s quality of life of a 4-week treatment with a shampoo containing 0.1% lipohydroxy acid and 1.3% salicylic acid found that the lip Hydroxy acid antifungal and exfoliating properties are likely to prove useful in combating dandruff.

Double-blind clinical trial for evaluating the effectiveness and tolerability of Ageratina pichinchensis extract on patients with mild to moderate onychomycosis. A comparative study with ciclopirox.

The therapeutic effectiveness and tolerability of topical administration of aerial parts of AGERATINA PICHINCHENSIS extract on the nails of patients with the clinical and mycological diagnosis of onychomycosis was evaluated.

Role of Topical Calcineurin Inhibitors in the Treatment of Seborrheic Dermatitis

Clinical trials of pimecrolimus and tacrolimus in the treatment of seborrheic dermatitis are reviewed, focusing on efficacy and safety.

Topical ketoconazole: a systematic review of current dermatological applications and future developments

Topical KTZ is clinically effective for the treatment of Malassezia-related conditions such as seborrheic dermatitis (SD) and pityriasis versicolor (PV) with a reported efficacy of 63–90% and 71–89%, respectively.

AVALIAÇÃO DE DIVERSAS FORMULAÇÕES DE XAMPUS DE CETOCONAZOL QUANTO AO EMPREGO DE DIFERENTES ANTIOXIDANTES E SOLUBILIZANTES EVALUTION OF SEVERAL FORMULATIONS OF KETOCONAZOLE SHAMPOOS FOR THE EMPLOYMENT OF DIFERENT ANTIOXIDANTS AND SOLUBILIZERS

Shampoos are products for cleaning or fixing substances in hair or scalp. Especially in the treatment products, the cleaning action can be accompanied by a pharmacological stimulant or normalizing

Ketoconazole or clotrimazole solution wash as a prophylaxis in management and prevention of fungal infection: a comparative study.

The objective of this study is to assess the effectiveness of prophylactic Ketoconazole or Clotrimazole solution wash in patients with fungal infections and to find out the response and recurrence.

In Vitro Anti-Malassezia Activity of Castanea crenata Shell and Oil-Soluble Glycyrrhiza Extracts

C. crenata shell and oil-soluble Glycyrrhiza extracts could potentially be used as active ingredients in anti-seborrheic and anti-dandruff shampoo formulations and could be helpful for repeated treatments and regular prophylaxis of scalp seborRheic dermatitis.

Ciclopirox: recent nonclinical and clinical data relevant to its use as a topical antimycotic agent.

Although less effective than some oral antimycotic agents in various indications, ciclopirox compares very well in terms of the benefit/risk ratio due to its excellent tolerability and complete absence of serious adverse effects.

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