Clinical effects of red‐bellied black snake (Pseudechis porphyriacus) envenoming and correlation with venom concentrations: Australian Snakebite Project (ASP‐11)

@article{Churchman2010ClinicalEO,
  title={Clinical effects of red‐bellied black snake (Pseudechis porphyriacus) envenoming and correlation with venom concentrations: Australian Snakebite Project (ASP‐11)},
  author={Andrew Churchman and Margaret A. O’Leary and Nicholas Alan Buckley and Colin B Page and Alan S Tankel and Chris F Gavaghan and Anna Holdgate and Simon G. A. Brown and Geoffrey K. Isbister},
  journal={Medical Journal of Australia},
  year={2010},
  volume={193}
}
Objective: To describe the clinical features and laboratory findings in patients with definite red‐bellied black snake (RBBS; Pseudechis porphyriacus) bites, including correlation with results of venom assays. 
Tiger snake (Notechis spp) envenoming: Australian Snakebite Project (ASP‐13)
TLDR
The clinical syndrome associated with definite tiger snake envenoming is described and the ability of tiger snake antivenom (TSAV) to bind free venom in vivo is examined. Expand
Severe rhabdomyolysis from red-bellied black snake (Pseudechis porphyriacus) envenoming despite antivenom.
TLDR
A case of severe rhabdomyolysis in a 16 year old male which developed despite early administration of one vial of tiger snake antivenom is presented and the use of larger doses of antivenoms need to be explored for red-bellied black snake envenoming. Expand
Red-bellied black snake (Pseudechis porphyriacus) envenomation in 17 dogs: clinical signs, coagulation changes, haematological abnormalities, venom antigen levels and outcomes following treatment with a tiger-brown snake antivenom.
TLDR
Some RBBS envenomed dogs required, critical care including mechanical ventilation, blood transfusion, additional antivenom and prolonged hospitalisation, and TBAV was effective with excellent prognosis despite stated specificity for tiger and brown snake. Expand
Red-bellied black snake (Pseudechis porphyriacus) envenomation in the dog: Diagnosis and treatment of nine cases.
  • A. Padula, K. Winkel
  • Medicine
  • Toxicon : official journal of the International Society on Toxinology
  • 2016
TLDR
The envenomation syndrome in dogs is similar to what is described for humans, with the exception of the presence of potentially severe venom induced consumption coagulopathy in one case (aPTT > 300 s and fibrinogen < 0.43 g/L) and potential for fatal outcomes. Expand
Investigating myotoxicity following Australian red-bellied black snake (Pseudechis porphyriacus) envenomation
TLDR
Early antivenom administration reduces the incidence of myotoxicity in patients following envenomation and indicates that the putative causative toxin’s concentration-time profile does not parallel that of venom. Expand
Diagnosis of snake envenomation using a simple phospholipase A2 assay
TLDR
Using a simple assay, potentially a bedside test, high phospholipase activity in sera of patients with viper and elapid envenomation compared to minimal activity in non-envenomed patients is detected. Expand
Population pharmacokinetics of Pseudechis porphyriacus (red-bellied black snake) venom in snakebite patients
TLDR
Investigation of the pharmacokinetics of red-bellied black snake (RBBS; Pseudechis porphyriacus) venom in envenomed patients to help improve treatment and the timing of antivenom found evidence of a double peak in the absorption profile. Expand
Mulga snake (Pseudechis australis) envenoming: a spectrum of myotoxicity, anticoagulant coagulopathy, haemolysis and the role of early antivenom therapy – Australian Snakebite Project (ASP-19)
TLDR
This study supports a dose of one vial of antivenom, given as soon as a systemic envenoming is identified, rather than waiting for the development of myotoxicity. Expand
Local morbidity from red-bellied black snake (Pseudechis porphyriacus, Elapidae) envenoming: Two cases and a brief review of management.
TLDR
The red-bellied black snake (Pseudechis porphyriacus, Elapidae) is one of several species of venomous snakes most commonly implicated in human and domestic animal envenoming in Australia and management of envenomed by this taxon is briefly reviewed. Expand
Pulmonary effects and complications of snakebites.
TLDR
Three common themes as reported in the literature regarding envenomation are identified: generalized neuromuscular paralysis affecting airway and respiratory muscles, pulmonary edema, and pulmonary hemorrhages or thrombosis due to coagulopathy. Expand
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TLDR
The present study investigated the in vitro neurotoxicity of venoms from seven Australasian Pseudechis species and determined the efficacy of black and tiger snake antivenoms against this activity. Expand
Envenoming by the rough‐scaled snake (Tropidechis carinatus): a series of confirmed cases
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The demographic, geographical and clinical features of envenoming by the rough‐scaled snake (RSS) (Tropidechis carinatus) are described. Expand
The envenomation syndrome caused by the Australian Red-bellied Black Snake Pseudechis porphyriacus.
TLDR
Five previously unreported cases of human envenomation in which the species diagnosis is secure are presented, including that of the Red-bellied Black Snake, the first terrestrial Australian elapid to be described and illustrated and the first to be the subject of experimental study. Expand
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  • Toxicon : official journal of the International Society on Toxinology
  • 1982
TLDR
The procoagulant properties of venous Australian snakes are limited to prothrombin activation and the actions of the venom of Oxyuranus scutellatus are dependent on concentration. Expand
Current use of Australian snake antivenoms and frequency of immediate‐type hypersensitivity reactions and anaphylaxis
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Investigation of current use of Australian snake antivenoms and the frequency and severity of immediate‐type hypersensitivity reactions to venomous snakes finds no consistency in results. Expand
On some effects upon the Blood produced by the Injection of the Venom of the Australian Black Snake (Pseudechis Porphyriacus)
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  • Chemistry, Medicine
  • The Journal of physiology
  • 1893
TLDR
This paper proposes to discuss one specific aspect of the physiological effect of the injection of the venom, which has become apparent during the course of the investigation the author is now carrying on, into the action of this poison on the animal oroganism. Expand
Collett's snake (Pseudechis colletti) envenoming in snake handlers.
TLDR
Collett's snake envenoming is characterized by early generalized systemic effects (nausea, vomiting, abdominal pain, diarrhoea and headache) and an anticoagulant coagulopathy, followed in some cases by rhabdomyolysis and acute renal failure in untreated patients within 24 h. Expand
The efficacy of two antivenoms against the in vitro myotoxic effects of black snake (Pseudechis) venoms in the chick biventer cervicis nerve-muscle preparation.
TLDR
The results of the present study suggest that Australasian Pseudechis venoms possess variable myotoxic activity and the ability of black or tiger snake antivenom to prevent or inhibit further venom-induced effects varied across the genus. Expand
Isolation of a hemolytic, toxic phospholipase from the venom of the Australian red-bellied black snake (Pseudechis porphyriacus).
TLDR
Modification of the toxin with p -bromophenacyl bromide resulted in a 99·9% loss of phospholipase activity and a reduction of its toxicity, and caused indirect hemolysis of washed erythrocytes. Expand
Enzyme immunoassays in brown snake (Pseudonaja spp.) envenoming: detecting venom, antivenom and venom-antivenom complexes.
TLDR
Serum samples were obtained from patients with brown snake envenoming before and after the administration of antivenom and patients with suspected brown snake bites but no evidence of envenomed patients. Expand
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