Clinical effects of red‐bellied black snake (Pseudechis porphyriacus) envenoming and correlation with venom concentrations: Australian Snakebite Project (ASP‐11)

  title={Clinical effects of red‐bellied black snake (Pseudechis porphyriacus) envenoming and correlation with venom concentrations: Australian Snakebite Project (ASP‐11)},
  author={Andrew Churchman and Margaret A. O’Leary and Nicholas Alan Buckley and Colin B Page and Alan S Tankel and Chris F Gavaghan and Anna Holdgate and Simon G. A. Brown and Geoffrey K. Isbister},
  journal={Medical Journal of Australia},
Objective: To describe the clinical features and laboratory findings in patients with definite red‐bellied black snake (RBBS; Pseudechis porphyriacus) bites, including correlation with results of venom assays. 

Tiger snake (Notechis spp) envenoming: Australian Snakebite Project (ASP‐13)

The clinical syndrome associated with definite tiger snake envenoming is described and the ability of tiger snake antivenom (TSAV) to bind free venom in vivo is examined.

Severe rhabdomyolysis from red-bellied black snake (Pseudechis porphyriacus) envenoming despite antivenom.

Red-bellied black snake (Pseudechis porphyriacus) envenomation in 17 dogs: clinical signs, coagulation changes, haematological abnormalities, venom antigen levels and outcomes following treatment with a tiger-brown snake antivenom.

Some RBBS envenomed dogs required, critical care including mechanical ventilation, blood transfusion, additional antivenom and prolonged hospitalisation, and TBAV was effective with excellent prognosis despite stated specificity for tiger and brown snake.

Red-bellied black snake (Pseudechis porphyriacus) envenomation in the dog: Diagnosis and treatment of nine cases.

  • A. PadulaK. Winkel
  • Medicine, Biology
    Toxicon : official journal of the International Society on Toxinology
  • 2016

Investigating myotoxicity following Australian red-bellied black snake (Pseudechis porphyriacus) envenomation

Early antivenom administration reduces the incidence of myotoxicity in patients following envenomation and indicates that the putative causative toxin’s concentration-time profile does not parallel that of venom.

Population pharmacokinetics of Pseudechis porphyriacus (red-bellied black snake) venom in snakebite patients

Investigation of the pharmacokinetics of red-bellied black snake (RBBS; Pseudechis porphyriacus) venom in envenomed patients to help improve treatment and the timing of antivenom found evidence of a double peak in the absorption profile.

Mulga snake (Pseudechis australis) envenoming: a spectrum of myotoxicity, anticoagulant coagulopathy, haemolysis and the role of early antivenom therapy – Australian Snakebite Project (ASP-19)

This study supports a dose of one vial of antivenom, given as soon as a systemic envenoming is identified, rather than waiting for the development of myotoxicity.

D‐dimer testing for early detection of venom‐induced consumption coagulopathy after snakebite in Australia (ASP‐29)

To assess the accuracy and marginal value of quantitative D‐dimer testing for diagnosing venom‐induced consumption coagulopathy (VICC) in people bitten by Australian snakes, a large number of people were bitten by venomous snakes.

Pulmonary effects and complications of snakebites.

Three common themes as reported in the literature regarding envenomation are identified: generalized neuromuscular paralysis affecting airway and respiratory muscles, pulmonary edema, and pulmonary hemorrhages or thrombosis due to coagulopathy.



Neurotoxic effects of venoms from seven species of australasian black snakes (Pseudechis): Efficacy of black and tiger snake antivenoms

The present study investigated the in vitro neurotoxicity of venoms from seven Australasian Pseudechis species and determined the efficacy of black and tiger snake antivenoms against this activity.

Envenoming by the rough‐scaled snake (Tropidechis carinatus): a series of confirmed cases

The demographic, geographical and clinical features of envenoming by the rough‐scaled snake (RSS) (Tropidechis carinatus) are described.

In vitro coagulant properties of venoms from Australian snakes.

Current use of Australian snake antivenoms and frequency of immediate‐type hypersensitivity reactions and anaphylaxis

Investigation of current use of Australian snake antivenoms and the frequency and severity of immediate‐type hypersensitivity reactions to venomous snakes finds no consistency in results.

On some effects upon the Blood produced by the Injection of the Venom of the Australian Black Snake (Pseudechis Porphyriacus)

This paper proposes to discuss one specific aspect of the physiological effect of the injection of the venom, which has become apparent during the course of the investigation the author is now carrying on, into the action of this poison on the animal oroganism.

Collett's snake (Pseudechis colletti) envenoming in snake handlers.

Collett's snake envenoming is characterized by early generalized systemic effects (nausea, vomiting, abdominal pain, diarrhoea and headache) and an anticoagulant coagulopathy, followed in some cases by rhabdomyolysis and acute renal failure in untreated patients within 24 h.

Comparative analysis of prothrombin activators from the venom of Australian elapids.

The molecular phylogenetic analysis described here represents a new approach for distinguishing group C and D snake prothrombin activators and correlates well with previous classifications.