Clinical effects of pharmacological variations in selective serotonin reuptake inhibitors: an overview

  title={Clinical effects of pharmacological variations in selective serotonin reuptake inhibitors: an overview},
  author={J. Carrasco and C. Sandner},
  journal={International Journal of Clinical Practice},
  • J. Carrasco, C. Sandner
  • Published 2005
  • Medicine
  • International Journal of Clinical Practice
  • Although the selective serotonin reuptake inhibitor (SSRI) class of antidepressants shares a common primary pharmacology, namely the inhibition of serotonin reuptake, their secondary pharmacology is remarkably heterogeneous. Inhibition of serotonin reuptake and the consequent increase in serotonin availability are responsible for the relief of depressive symptoms and for some of the adverse effects of this class of drugs. Transsynaptic effects such as modulation of signalling cascades, gene… CONTINUE READING
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