Clinical effects of pharmacological variations in selective serotonin reuptake inhibitors: an overview

@article{Carrasco2005ClinicalEO,
  title={Clinical effects of pharmacological variations in selective serotonin reuptake inhibitors: an overview},
  author={Jos{\'e} Luis Carrasco and C Sandner},
  journal={International Journal of Clinical Practice},
  year={2005},
  volume={59}
}
  • J. CarrascoC. Sandner
  • Published 1 December 2005
  • Psychology, Biology
  • International Journal of Clinical Practice
Although the selective serotonin reuptake inhibitor (SSRI) class of antidepressants shares a common primary pharmacology, namely the inhibition of serotonin reuptake, their secondary pharmacology is remarkably heterogeneous. Inhibition of serotonin reuptake and the consequent increase in serotonin availability are responsible for the relief of depressive symptoms and for some of the adverse effects of this class of drugs. Transsynaptic effects such as modulation of signalling cascades, gene… 

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Pharmacological interaction with the sigma1 (σ1)-receptor in the acute behavioral effects of antidepressants.

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Transgenic elimination of high-affinity antidepressant and cocaine sensitivity in the presynaptic serotonin transporter

Transgenic mice in which high-affinity recognition of multiple antidepressants and cocaine is eliminated are developed and it is established directly that SERT is the sole protein responsible for selective 5-HT reuptake inhibitor-mediated alterations in 5-hydroxytryptamine clearance, in5-HT1A autoreceptor modulation of raphe neuron firing, and in behaviors used to predict the utility of antidepressants.
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