Clinical effects of intravenously administered dantrolene.

  title={Clinical effects of intravenously administered dantrolene.},
  author={Denise J. Wedel and John G Quinlan and Paul Anthony Iaizzo},
  journal={Mayo Clinic proceedings},
  volume={70 3},
OBJECTIVE To compare side effects after intravenous administration of dantrolene sodium in subjects susceptible to and those nonsusceptible to malignant hyperthermia (MHS and MHN, respectively). DESIGN We studied two groups, six patients thought to be MHS and six assumed MHN subjects, and analyzed their responses to intravenously administered dantrolene. MATERIAL AND METHODS Dantrolene (3 mg/kg) was administered slowly into an antecubital vein, and blood samples were withdrawn from the… CONTINUE READING