Clinical effects of gonadotropin-releasing hormone analogue in metastatic carcinoma of prostate.

@article{Smith1985ClinicalEO,
  title={Clinical effects of gonadotropin-releasing hormone analogue in metastatic carcinoma of prostate.},
  author={Joseph Alexander Smith and Leonard Michael Glod{\'e} and Julie Wettlaufer and Barry S. Stein and Andrew Glass and D T Max and D Anbar and C L Jagst and Gerald P. Murphy},
  journal={Urology},
  year={1985},
  volume={25 2},
  pages={106-14}
}
Leuprolide is a new, potent analogue of gonadotropin-releasing hormone which, after an initial transient stimulation, causes a profound suppression of serum gonadotropins and testosterone. One hundred eighteen patients with advanced carcinoma of the prostate have undergone treatment with leuprolide in a multi-institutional trial. Minimal evidence of objective response was seen in patients who had failed prior endocrine therapy with orchiectomy or estrogens. In patients without previous hormonal… CONTINUE READING