Clinical effects of endothelin receptor antagonism with bosentan in patients with severe chronic heart failure: results of a pilot study.

@article{Packer2005ClinicalEO,
  title={Clinical effects of endothelin receptor antagonism with bosentan in patients with severe chronic heart failure: results of a pilot study.},
  author={Milton Packer and J. McMurray and Barry M. Massie and Abraham Caspi and Vincent Charlon and Alain Cohen-Sol{\'a}l and Wolfgang Kiowski and William J. Kostuk and Henry Krum and Barry Levine and Paolo Rizzon and Jordi Soler Soler and Karl Swedberg and Susan D Anderson and David DeMets},
  journal={Journal of cardiac failure},
  year={2005},
  volume={11 1},
  pages={12-20}
}
BACKGROUND Endothelin receptor antagonism produces favorable short-term hemodynamic effects in heart failure, but the clinical effects of longer term therapy have not been evaluated. METHODS AND RESULTS Three hundred and seventy patients with symptoms of heart failure at rest or on minimal exertion and a left ventricular ejection fraction <35% were randomly assigned (double-blind) to placebo (n = 126) or the endothelin receptor antagonist bosentan, titrated slowly (n = 121) or rapidly (n… CONTINUE READING