Clinical effects of calcium channel blockers and renin-angiotensin-aldosterone system inhibitors on changes in the estimated glomerular filtration rate in patients with polycystic kidney disease

@article{Mitobe2010ClinicalEO,
  title={Clinical effects of calcium channel blockers and renin-angiotensin-aldosterone system inhibitors on changes in the estimated glomerular filtration rate in patients with polycystic kidney disease},
  author={Michihiro Mitobe and Takumi Yoshida and Hidekazu Sugiura and Shunji Shiohira and Katsunori Shimada and Kosaku Nitta and Ken Tsuchiya},
  journal={Clinical and Experimental Nephrology},
  year={2010},
  volume={14},
  pages={573-577}
}
In the tubular cells of patients with polycystic kidney disease (PKD), a reduced intracellular Ca2+ level accelerates cell proliferation, resulting in cyst formation. Thus, whether calcium channel blockers (CCB) are useful for the treatment of hypertension in patients with PKD is questionable. Thirty-two outpatients with autosomal dominant PKD (ADPKD) were treated at Tokyo Women's Medical University between 2003 and 2008; these patients were studied retrospectively. Periods during which the… CONTINUE READING
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