Clinical effects of apomorphine in schizophrenia.

  title={Clinical effects of apomorphine in schizophrenia.},
  author={I. Nicol Ferrier and Eve C. Johnstone and Timothy John Crow},
  journal={The British journal of psychiatry : the journal of mental science},
There have been reports that low doses of the dopamine-agonist apomorphine, which may inhibit dopamine neurotransmission, are of therapeutic benefit in schizophrenia. We conducted a placebo-controlled study of acute and chronic schizophrenics in which videotaped interviews were blindly rated. No specific therapeutic effect was demonstrated for apomorphine other than a reduction in anxiety in acute schizophrenics. Furthermore, there was no difference in the frequency of side-effects of… CONTINUE READING