Clinical doses of atomoxetine significantly occupy both norepinephrine and serotonin transports: Implications on treatment of depression and ADHD

@article{Ding2014ClinicalDO,
  title={Clinical doses of atomoxetine significantly occupy both norepinephrine and serotonin transports: Implications on treatment of depression and ADHD},
  author={Yu-Shin Ding and M. Naganawa and J. Gallezot and N. Nabulsi and Shu-Fei Lin and J. Ropchan and D. Weinzimmer and T. McCarthy and R. Carson and Yiyun Huang and M. Laruelle},
  journal={NeuroImage},
  year={2014},
  volume={86},
  pages={164-171}
}
BACKGROUND Atomoxetine (ATX), a drug for treatment of depression and ADHD, has a high affinity for the norepinephrine transporter (NET); however, our previous study showed it had a blocking effect similar to fluoxetine on binding of [(11)C]DASB, a selective serotonin transporter (SERT) ligand. Whether the therapeutic effects of ATX are due to inhibition of either or both transporters is not known. Here we report our comparative PET imaging studies with [(11)C]MRB (a NET ligand) and [(11)C]AFM… Expand
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