Clinical diagnosis of Alzheimer's disease

@article{Mckhann1984ClinicalDO,
  title={Clinical diagnosis of Alzheimer's disease},
  author={Guy Mckhann and David A. Drachman and Marshal F. Folstein and Robert Katzman. and Donald Price and Emanuel M. Stadlan},
  journal={Neurology},
  year={1984},
  volume={34},
  pages={939 - 939}
}
Clinical criteria for the diagnosis of Alzheimer's disease include insidious onset and progressive impairment of memory and other cognitive functions. There are no motor, sensory, or coordination deficits early in the disease. The diagnosis cannot be determined by laboratory tests. These tests are important primarily in identifying other possible causes of dementia that must be excluded before the diagnosis of Alzheimer's disease may be made with confidence. Neuropsychological tests provide… 

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References

SHOWING 1-10 OF 38 REFERENCES
The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects
TLDR
The expectation of mental disorder shows a steep increase with advancing chronological age, and beyond 75 years a large part of this increase is accounted for by disorders associated with degenerative changes in the central nervous system for which the authors lack remedies at the present time.
Cerebral blood flow in dementia
To the Editor: Dr. Rogers et all demonstrated a decrease in cerebral blood flow (CBF) long before there was clinical evidence of vascular dementia, but CBF was relatively preserved in patients with
Normative data on the boston diagnostic aphasia examination, parietal lobe battery, and the boston naming Test
Abstract This report describes normative data for the Boston Diagnostic Aphasia Examination, the “Parietal Lobe Battery” (Goodglass & Kaplan, 1972), and the Boston Naming Test (Kaplan, Goodglass, &
STUDIES OF ILLNESS IN THE AGED. THE INDEX OF ADL: A STANDARDIZED MEASURE OF BIOLOGICAL AND PSYCHOSOCIAL FUNCTION.
TLDR
The observation that theOrder of recovery of Index functions in disabled patients is remarkably similar to the order of development of primary functions in children suggests that the Index is based on primary biological and psychosocial function, reflecting the adequacy of organized neurological and locomotor response.
Interactive effects of age and brain disease on reaction time.
  • A. Benton
  • Psychology, Medicine
    Archives of neurology
  • 1977
TLDR
Analysis indicated an interactive effect of age and brain disease on RT supporting the suggestion that acquired brain disease leads to a more pronounced retardation in RT in older patients.
The Reporter's Test: a sensitive test to detect expressive disturbances in aphasics.
  • E. De Renzi, C. Ferrai
  • Psychology, Medicine
    Cortex; a journal devoted to the study of the nervous system and behavior
  • 1978
The Assessment of Aphasia and Related Disorders
Originally published in Contemporary Psychology: APA Review of Books, 1972, Vol 17(11), 614. Reviews the book, The Assessment of Aphasia and Related Disorders by Harold Goodglass (1972). This small
Development of a rating scale for primary depressive illness.
  • M. Hamilton
  • Psychology
    The British journal of social and clinical psychology
  • 1967
This is an account of further work on a rating scale for depressive states, including a detailed discussion on the general problems of comparing successive samples from a ‘population’, the meaning of
...
...