Clinical development of reovirus for cancer therapy: An oncolytic virus with immune-mediated antitumor activity.

@article{Gong2016ClinicalDO,
  title={Clinical development of reovirus for cancer therapy: An oncolytic virus with immune-mediated antitumor activity.},
  author={Jun Gong and Esha Sachdev and Alain C. Mita and Monica M. Mita},
  journal={World journal of methodology},
  year={2016},
  volume={6 1},
  pages={
          25-42
        }
}
Reovirus is a double-stranded RNA virus with demonstrated oncolysis or preferential replication in cancer cells. The oncolytic properties of reovirus appear to be dependent, in part, on activated Ras signaling. In addition, Ras-transformation promotes reovirus oncolysis by affecting several steps of the viral life cycle. Reovirus-mediated immune responses can present barriers to tumor targeting, serve protective functions against reovirus systemic toxicity, and contribute to therapeutic… CONTINUE READING
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