Clinical development of 17-allylamino, 17-demethoxygeldanamycin.

  title={Clinical development of 17-allylamino, 17-demethoxygeldanamycin.},
  author={Edward A. Sausville and Joseph E. Tomaszewski and Percy S. Ivy},
  journal={Current cancer drug targets},
  volume={3 5},
17-allylamino, 17-demethoxygeldanamycin (17AAG; NSC 330507) is the first modulator of heat shock protein 90 (Hsp90) to enter clinical trials. Hsp90 serves a chaperone role to properly fold and deliver client proteins to appropriate intracellular locations. Interest in Hsp90 modulators for the experimental therapeutics of cancer has arisen based on pre-clinical evaluations suggesting that Hsp90 client proteins regulate signaling pathways critical to the molecular economy of many types of tumors… CONTINUE READING


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