Clinical course of cow's milk protein allergy/intolerance and atopic diseases in childhood

  title={Clinical course of cow's milk protein allergy/intolerance and atopic diseases in childhood},
  author={Arne H{\o}st and Susanne Halken and H P Jacobsen and Anne E. Christensen and Anne Maria Herskind and Karin Bruun Plesner},
  journal={Pediatric Allergy and Immunology},
A cohort of 1,749 newborns from the municipality of Odense, born during 1995 at the Odense University Hospital, were followed up prospectively for the development of cow's milk protein allergy/intolerance (CMPA/I) during the first year of life. Once a diagnosis of CMPA/I was confirmed, a milk‐free diet was continued until a new milk challenge had shown development of tolerance. All infants with CMPA/I were rechallenged at 12 months of age and, in the event of continued clinical sensitivity to… 

Retrospective Evaluation of Cases with Cow’s Milk Allergy

Clinical parameters and allergy tests may help to predict the prognosis of CMA, and milk-specific IgE level at the time of diagnosis is the risk factor for persistent CMA.

Lessons from the clinical course of IgE‐mediated cow milk allergy in Israel

  • Y. LevyN. SegalB. GartyY. Danon
  • Medicine
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
  • 2007
Less than half of the children diagnosed with IgE‐mediated CMA during 9 yr, outgrew it, and the patients with persistent CMA have a higher prevalence of asthma compared with the general population or to children with transient CMA.

The natural course of cow’s milk allergy and the development of atopic diseases into adulthood

The natural course of CMA in a 1‐year birth cohort of Danish children from birth until 15 and 26 years of age and the development of atopic diseases in a group of children with CMA compared to a random sample of 276 children from the same birth cohort are investigated.

Natural history of immunoglobulin E-mediated cow's milk allergy in a population of Argentine children.

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IgE-Mediated Cow’s Milk Allergy in Iranian Infants and Children: Predictive Factors of Early Tolerance

The findings showed that about one half of the infants and children with IgE-mediated cow’s milk allergy grew out of it over 18 months of follow-up (mean age 2 years); atopic dermatitis and parental allergy can predict this outcome.

Studies in cow’s milk allergy: results from the Dutch EuroPrevall birth cohort

In this European, multicentre study, nine European hospitals followed over 12,000 children from birth up to 2.5 years of age, some hereditary components for cow’s milk allergy were identified and a hypermethylation was found with epigenetic investigations in children with cow's milk allergy compared to healthy age-matched controls.

Atopic dermatitis incident in the first 6 months of life.

Predicting the risk of allergies and avoiding of hyperallergenic milk formula is the key in preventing the occurrence of AD in the first 6 months of life.

Genetic susceptibility for cow’s milk allergy in Dutch children: the start of the allergic march?

This work significantly associated two SNPs with CMA, suggesting that variation in the TLR6 and IL2 genes contribute to the expression of CMA and favours the “allergic march” hypothesis.



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A Prospective Study of Cow's Milk Allergy in Exclusively Breast‐Fed Infants

Review of records from the newborn nursery revealed that all 9 infants had been exposed to cow's milk formula in amounts corresponding to approximately 0.4‐3.0 g of Beta‐lactoglobulin (BLG) during the first three days of life.

Effect of an allergy prevention programme on incidence of atopic symptoms in infancy

Feeding with breastmilk and/or hypoallergenic formula combined with avoidance of solid foods until the age of 6 months appeared to reduce the cumulative prevalence of atopic symptoms during the first 18 months of life.

Cow's milk protein allergy and intolerance in infancy Some clinical, epidemiological and immunological aspects

  • A. Høst
  • Medicine
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
  • 1994
The degree of antibody response to CMP exposure is a better predictor of persisting CMPA than a single finding of an elevated antibody level which can occur in normal infants without CMPA/CMPI.

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Screening of total IgE in 2814 cord blood samples was analysed by Phadebas IgE PRIST in 2 1‐year birth cohorts in Denmark and significantly more infants with a family history of atopic disease developed atopy at 18 months.

Cord blood IgE levels are influenced by gestational age but do not predict allergic manifestations in infants

It is concluded that cord blood IgE can not be used to predict allergic manifestations in children under the age of 2 years.

Recurrent wheezing in relation to environmental risk factors in infancy

Low social status, daycare, daily contact with furred pets, having carpeted floor in bedroom, and living in a flat proved not to affect significantly the risk of recurrent wheezing.

Allergic reactions to raw, pasteurized, and homogenized/pasteurized cow milk: a comparison

A tendency towards a lower threshold of reaction and larger skin reactions induced by the processed milk preparations might indicate an increased ability of pasteurized and homogenized/pasteurized milk to evoke allergic reactions in patients allergic to milk.

Cord blood

Screening of total IgE in 2814 cord blood samples was analysed by Phadebas IgE PRIST in 2 1‐year birth cohorts in Denmark and found no correlation between cord blood IgE and birth weight or gestational age, indicating infrequent contamination with maternal blood.

Cord blood IgE. III. Prediction of IgE high‐response and allergy

A statistically significant correlation between cord blood IgE and IgE at 18 months of age was found and a cut‐off value of 0.3 kU/1 for cordBlood IgE was superior to the originally suggested 0.5 kU /1.