Clinical course and long‐term prognosis of acute transverse myelopathy

@article{Christensen1990ClinicalCA,
  title={Clinical course and long‐term prognosis of acute transverse myelopathy},
  author={Peter Broegger Christensen and Lene Wermuth and H H Hinge and K. B{\o}emers},
  journal={Acta Neurologica Scandinavica},
  year={1990},
  volume={81}
}
The clinical characteristics and course of acute transverse myelopathy (ATM) was studied. One patient developed multiple sclerosis. In 1 patient ATM was caused by tumour‐cell embolization of the intramedullar vessels; 30 aged 12–74 years (median 36 years) had ATM of unknown course, of these, 13 had symptoms of a preceding viral‐like infection, 18 had back‐pain and 10 signs of spinal shock. The time from onset of ATM to maximum deficit varied from less than 1 h to 20 days. The thoracic region… 

Long-term outcome of acute and subacute myelopathies

Over half of patients initially diagnosed with myelopathy of undetermined cause subsequently developed multiple sclerosis, NMO or SD, and ASM is a severe condition with a bad or fair functional outcome and a major impact on professional activity in one-third of the patients.

Acute transverse myelitis in childhood

Persisting disability was present in many children with acute transverse myelitis and age at onset below 3 years was associated with worse functional outcomes, while older age at time of diagnosis was associatedwith a better functional outcome.

Acute myelopathies: Clinical, laboratory and outcome profiles in 79 cases.

Aetiologies of AM may be differentiated on the basis of clinical, spinal cord and brain MRI, CSF and outcome data, and allow a probable diagnosis to be made in previously undetermined cases, and may have therapeutic implications for cases with a questionable diagnosis.

MRI in acute transverse myelopathy

The outcome was grave in the majority of patients and there seemed to be a correlation between the degree of cord enlargement, persistence of increased signal intensity and limited recovery.

Recent advances in prognostic factors of acute transverse myelitis

The etiology of acute transverse myelitis (ATM) is still unclear, and it is currently thought to be related with autoimmune responses caused by infection. Spinal cord edema caused by ATM can leads to

Progressive ascending myelopathy: atypical forms of multiple sclerosis or what else?

In the opinion, the more suitable diagnosis is an atypical form of MS although it is not possible to exclude a new nosological entity that could be included in the expanding range of spinal cord diseases.

Acute transverse myelitis in demyelinating diseases among the Chinese

The length of spinal cord lesion, rather than APTM/ACTM, may be a prognostic factor associated with clinical outcome and long-term disability in Chinese patients with ATM.

Etiologic spectrum and functional outcome of the acute inflammatory myelitis

AIM is a heterogeneous syndrome from an etiological point of view and LETM patients had worse functional prognosis compared with PL after 3 and 6 months.

Idiopathic transverse myelitis: an experience in a tertiary care setup.

It did not behave very differently from what is reported in the international literature, with myelitis most commonly involving the dorsal spine, spanning over more than two spinal segments and showing complete or partial recovery in majority of cases with timely presentation for treatment.
...

References

SHOWING 1-10 OF 31 REFERENCES

The prognosis of acute and subacute transverse myelopathy based on early signs and symptoms

Because of the frequency with which mass lesions were missed, the need for myelography in the diagnosis of TM is emphasized and multiple sclerosis evolved in 7 patients during the follow‐up period.

Acute transverse myelopathy in adults. A follow-up study.

The only factor which correlated with prognosis was the observation that patients who retained tendon reflexes and posterior column function had a better recovery than those who exhibited spinal shock.

ACUTE TRANSVERSE MYELOPATHY.

Despite its clinical recognition for several decades and its not infrequent occurrence, acute transverse myelopathy remains a poorly understood syndrome not only etiologically but also in terms of

Acute transverse myelitis

No significant difference was noted between European American-born and Afro/Asian-born populations and there was no significant seasonal or annual fluctuation in frequency of acute transverse myelitis.

Transverse myelopathy in childhood.

The purpose of the present article is to present 25 cases of transverse myelopathy in childhood and to consider their implications as to etiology, prognosis, and plan of management.

Absence of evoked potential abnormalities in acute transverse myelopathy

Patients with inflammatory acute transverse myelopathy and no prior history of neurologic disease had normal pattern shift visual and brainstem auditory evoked potentials and none developed new neurologic signs in 18 months' mean follow-up, compared with patients with definite, probable, or possible multiple sclerosis.

Evoked potentials in acute transverse myelopathy.

Evoked potential studies were undertaken in nine patients with acute transverse myelopathy three to 25 weeks after onset, finding that oedema and necrosis in the central nervous system, whereas demyelination probably plays a minor role in acute Transverse Myelopathy.

Evoked potentials in acute transverse myelopathy.

  • C. Wulff
  • Medicine
    Danish medical bulletin
  • 1985
The findings are attributed to oedema and necrosis in the central nervous system, whereas demyelination probably plays a minor role in acute transverse myelopathy.

Acute myelopathy associated with primary infection with human immunodeficiency virus.

A 29 year old white homosexual man presented with a two and a half week history of severe sore throat, fever, and extreme fatigue and developed abnormal neurological signs, including a paraparesis and hyperreflexia of the arms, probably the first report of a patient with myelopathy at the time of seroconversion.

Herpes zoster myelitis. Evidence for viral invasion of spinal cord.

Cowdry type A intranuclear inclusion bodies and structures in glial cells consistent with nucleocapsids of herpesvirus were observed in cervical spinal cord and the findings suggest that herpes zoster myelitis is mediated by direct viral invasion and cell lysis.