Clinical course, pathological correlations, and outcome of biopsy proved inflammatory demyelinating disease.

@article{Pittock2005ClinicalCP,
  title={Clinical course, pathological correlations, and outcome of biopsy proved inflammatory demyelinating disease.},
  author={Sean Joseph Pittock and R. L. Mcclelland and Sara J. Achenbach and Friedhelm Konig and Andreas Bitsch and Wolfgang Br{\"u}ck and Hans Lassmann and Joseph E. Parisi and Bernd Walter Scheithauer and Moses Rodriguez and Brian G. Weinshenker and C F Lucchinetti},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={2005},
  volume={76 12},
  pages={
          1693-7
        }
}
BACKGROUND A pathological classification has been developed of early active multiple sclerosis (MS) lesions that reveals four patterns of tissue injury: I-T cell/macrophage associated; II-antibody/complement associated; III-distal oligodendrogliopathy, and IV-oligodendrocyte degeneration in the periplaque white matter. Mechanisms of demyelination in early MS may differ among the subgroups. Previous studies on biopsied MS have lacked clinicopathological correlation and follow up. Critics argue… CONTINUE READING
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