Clinical correlation of variations in the internal transcribed spacer regions of rRNA genes in Pneumocystis carinii f.sp. hominis.

@article{HelwegLarsen2001ClinicalCO,
  title={Clinical correlation of variations in the internal transcribed spacer regions of rRNA genes in Pneumocystis carinii f.sp. hominis.},
  author={Jannik Helweg-Larsen and Carol H Lee and Shaoling Jin and J Y Hsueh and Thomas Benfield and John Mark Hansen and Jens D. Lundgren and Bettina Lundgren},
  journal={AIDS},
  year={2001},
  volume={15 4},
  pages={451-9}
}
OBJECTIVES To analyse the importance of sequence variations in the internal transcribed spacer (ITS) regions 1 and 2 of the nuclear rRNA operon in AIDS patients with Pneumocystis carinii pneumonia (PCP). DESIGN AND METHODS ITS 1 and 2 genotypes were determined in 162 bronchoalveolar lavage samples from 130 patients participating in a prospective cohort study of PCP. RESULTS A total of 49 different ITS genotypes were detected. ITS genotype was not associated with the clinical severity or… CONTINUE READING
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