Clinical correlates of JAK2V617F allele burden in essential thrombocythemia.

  title={Clinical correlates of JAK2V617F allele burden in essential thrombocythemia.},
  author={Jaya Kittur and Ryan A. Knudson and Terra L. Lasho and Christy M. Finke and Naseema Gangat and Alexandra P. Wolanskyj and C Y Li and Wenting Wu and Rhett P. Ketterling and Animesh Pardanani and Ayalew Tefferi},
  volume={109 11},
BACKGROUND JAK2V617F occurs in approximately 50% of patients with essential thrombocythemia (ET). Qualitative studies of mutation analysis have previously reported an association between JAK2V617F and advanced age, higher hemoglobin level, higher leukocyte count, and lower platelet count. A possible association with thrombotic complication has also been considered. METHODS Allele-specific, quantitative polymerase chain reaction (PCR) analysis for JAK2V617F was performed in 176 patients with… CONTINUE READING


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