Clinical correlates in an experimental model of repetitive mild brain injury.

  title={Clinical correlates in an experimental model of repetitive mild brain injury.},
  author={Rebekah C. Mannix and William Meehan and Joseph B. Mandeville and P. Ellen Grant and Tory Gray and Jacqueline B Berglass and Jimmy Zhang and John Bryant and Shervin Rezaie and Joon Yong Chung and Nicholas V Peters and Christopher C H Lee and Lee W. Tien and David L Kaplan and Mel B. Feany and Michael Whalen},
  journal={Annals of neurology},
  volume={74 1},
OBJECTIVE Although there is growing awareness of the long-term cognitive effects of repetitive mild traumatic brain injury (rmTBI; eg, sports concussions), whether repeated concussions cause long-term cognitive deficits remains controversial. Moreover, whether cognitive deficits depend on increased amyloid β deposition and tau phosphorylation or are worsened by the apolipoprotein E4 allele remains unknown. Here, we use an experimental model of rmTBI to address these clinical controversies… CONTINUE READING
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