Clinical control and histopathologic outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment. The AMPUL Study Group.

@article{Sont1999ClinicalCA,
  title={Clinical control and histopathologic outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment. The AMPUL Study Group.},
  author={Jaap K Sont and Luuk N. A. Willems and Elisabeth H. D. Bel and J Han Van Krieken and Jan Paul Vandenbroucke and Peter J. Sterk},
  journal={American journal of respiratory and critical care medicine},
  year={1999},
  volume={159 4 Pt 1},
  pages={
          1043-51
        }
}
According to international guidelines, the level and adjustment of antiinflammatory treatment for asthma are based solely on symptoms and lung function. We investigated whether a treatment strategy aimed at reducing airway hyperresponsiveness (AHR strategy) in addition to the recommendations in the existing guidelines (reference strategy) led to: (1) more effective control of asthma; and (2) greater improvement of chronic airways inflammation. To accomplish this, we conducted a randomized… CONTINUE READING

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