Clinical concepts for regenerative therapy in intrabony defects.

@article{Cortellini2015ClinicalCF,
  title={Clinical concepts for regenerative therapy in intrabony defects.},
  author={Pierpaolo Cortellini and Maurizio S. Tonetti},
  journal={Periodontology 2000},
  year={2015},
  volume={68 1},
  pages={
          282-307
        }
}
Evidence indicates that periodontal regeneration is an efficacious and predictable procedure for the treatment of isolated and multiple intrabony defects. Meta-analyses from systematic reviews indicate an added benefit, in terms of clinical attachment level gain, when demineralized freeze-dried bone allograft, barrier membranes and active biologic products/compounds are applied in addition to open flap debridement. On the other hand, a consistent amount of variability of the outcomes is evident… 
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118 Citations

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Citation Type

Guided tissue regeneration combined with bone allograft in infrabony defects: Clinical outcomes and assessment of prognostic factors.
TLDR
Data suggests GTR is a good option for the treatment of infrabony defects since it can improve both tooth retention rate and overall clinical outcomes.
Combination Therapy for Reconstructive Periodontal Treatment in the Lower Anterior Area: Clinical Evaluation of a Case Series
TLDR
It is concluded that the present combination therapy for reconstructive periodontal treatment in the lower anterior area is a valuable alternative for indicated cases.
Effect of systemic antibiotics on the outcomes of regenerative periodontal surgery in intrabony defects: a randomized, controlled, clinical study
TLDR
The present study has failed to show any substantial added clinical benefits following the postoperative administration of amoxicillin in conjunction with regenerative periodontal surgery, and the post-surgically administration of systemic antibiotics does not seem to be necessary following regenerative Periodontal Surgery.
Periodontal infrabony defects: systematic review of healing by defect morphology following regenerative surgery.
TLDR
Deeper defects with narrower angles and increased number of walls exhibit improved CAL and radiographic bone gain at 12 months post-regenerative surgery, finding that infrabony defect morphology affects the outcome of periodontal regenerative surgery.
Regenerative surgery versus access flap for the treatment of intrabony periodontal defects. A systematic review and meta-analysis.
TLDR
EMD or GTR in combination with papillary preservation flaps should be considered the treatment of choice for residual pockets with deep (≥3mm) intrabony defects.
Nanocrystalline hydroxyapatite in regeneration of periodontal intrabony defects: A systematic review and meta-analysis.
Ten-Year Stability of Clinical Attachment after Regenerative Treatment of Infrabony Defects and Controls
TLDR
Regenerative treatment of IBDs exhibited stability comparable to non-surgically treated, periodontally reduced sites over a 10-year period.
Cell-based therapies for the surgical treatment of periodontal intrabony defects: a systematic review.
TLDR
Cell-based therapies have been positively applied for the surgical treatment of intrabony periodontal defects with promising results, however, the results obtained should be interpreted with caution due to the low number of available RCTs, the study design heterogeneity, and the limited extension of the follow-up.
Clinical and radiographic evaluation of amnion chorion membrane and demineralized bone matrix putty allograft for management of periodontal intrabony defects: a randomized clinical trial
TLDR
Both ACM barrier and DBM putty allograft provided significant improvement in clinical and radiographic outcomes after 6 months, yet no significant differences were noticed between them, implying that both biomaterials have a potential regenerative capacity in treating periodontal intrabony defects.
Interproximal attachment gain: The challenge of periodontal regeneration.
TLDR
A state-of-the-art review on surgical reconstructive approaches for treating papillary deficiency associated with soft and hard tissue interproximal defects and how combination therapy of papilla preservation, connective tissue grafting and coronally advanced flaps may result in regeneration of the intrabony defect coupled with root coverage.
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References

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TLDR
The use of an evidence-based regenerative strategy resulted in clinically relevant amounts of CAL gains, shallow pockets, and minimal gingival recession with the four regenerative approaches.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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