Clinical characteristics of patients with malignant pleural mesothelioma harboring somatic BAP1 mutations.

@article{Zauderer2013ClinicalCO,
  title={Clinical characteristics of patients with malignant pleural mesothelioma harboring somatic BAP1 mutations.},
  author={Marjorie G. Zauderer and Matthew Bott and Robert McMillan and Camelia S. Sima and Valerie M Rusch and Lee Krug and Marc Ladanyi},
  journal={Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
  year={2013},
  volume={8 11},
  pages={1430-3}
}
INTRODUCTION Genomic studies of malignant pleural mesothelioma (MPM) have recently identified frequent mutations in the BRCA-associated protein 1(BAP1) gene. In uveal melanoma and clear cell renal cell carcinoma, BAP1 mutations are associated with poor outcomes but their clinical significance in MPM is unknown. We therefore undertook this study to define the characteristics of patients whose MPM tumors harbor somatic BAP1 mutation and to examine the relationship between BAP1 mutation and… CONTINUE READING
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