Clinical characteristics and pharmacokinetics of purified soy isoflavones: single-dose administration to healthy men.

@article{Busby2002ClinicalCA,
  title={Clinical characteristics and pharmacokinetics of purified soy isoflavones: single-dose administration to healthy men.},
  author={Marjorie G. Busby and A. Robert Jeffcoat and Leanne T Bloedon and Matthew A. Koch and Tracy M Black and Kelly J. Dix and William D. Heizer and Brian F. Thomas and Judith M. Hill and James A. Crowell and Steven H Zeisel},
  journal={The American journal of clinical nutrition},
  year={2002},
  volume={75 1},
  pages={126-36}
}
BACKGROUND Soy isoflavones are potential cancer chemoprevention treatments. OBJECTIVE We conducted safety studies of purified unconjugated genistein, daidzein, and glycitein, and defined pharmacokinetic parameters for their absorption and metabolism. DESIGN Thirty healthy men ingested a single dose of 1 of 2 isoflavone preparations purified from soy. The delivered doses of genistein (1, 2, 4, 8, or 16 mg/kg body wt) were higher than those previously administered to humans. Formulation A was… CONTINUE READING

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