Clinical biochemistry of dihydrotestosterone
@article{Marchetti2013ClinicalBO,
title={Clinical biochemistry of dihydrotestosterone},
author={Paula Marchetti and Julian H. Barth},
journal={Annals of Clinical Biochemistry},
year={2013},
volume={50},
pages={107 - 95},
url={https://api.semanticscholar.org/CorpusID:8325257}
}The physiology of D HT production and action is described, current concepts in the role of DHT in the pathogenesis of various disorders of sexual development are summarized, current methods for the measurement are compared, and a conclusion on the clinical utility ofDHT measurement is concluded.
66 Citations
Preliminary Reference Interval for 5-Alpha Reductase in Normal Male Children and Its Association with Hypospadias.
- 2022
Medicine
Its levels falls considerably with clinical severity of hypospadias, reinforcing the importance of the enzyme in the development of male external genitalia.
associations between serum dihydrotestosterone levels, lipid parameters & anthropometric measurements in male patients with type 2 diabetes mellitus
- 2022
Medicine
The levels of serum dihydrotestosterone were significantly lower in diabetic cases than in healthy controls, and 90 percent of Type 2 diabetics were found to have subnormal levels, as opposed to just 10 percent of controls.
Clinical implications of estrone sulfate measurement in laboratory medicine
- 2017
Medicine
E1S has some interesting potential applications in clinical laboratory medicine that require further investigation and is highlighted in the literature that suggests the possible advantages of measuring E1S in addition to, or possibly in place of, the more commonly measured estradiol (E2) and the less common measured estrone (E1).
Progesterone in gender-affirming therapy of trans women
- 2022
Medicine
The present article explores potential clinical implications from the addition of bioidentical progesterone to gender-affirming treatment of trans women and speculates on possible benefits for gender transitioning.
Non-Classic Disorder of Adrenal Steroidogenesis and Clinical Dilemmas in 21-Hydroxylase Deficiency Combined with Backdoor Androgen Pathway. Mini-Review and Case Report
- 2020
Medicine
Investigations provided evidence that the girl suffered from non-classic 21α-hydroxylase deficiency with consequent enhancement of the androgen “backdoor” pathway in adrenals, peripheral tissues or both, using adrenal origin precursors.
The Roles of Androgens in Humans: Biology, Metabolic Regulation and Health
- 2022
Medicine, Biology
The clinical use of T to correct hypoandrogenism helps maintain the functionality of core metabolism, limiting excess fat deposition, sarcopenia and cognoscitive frailty and the effectiveness of using lipophilic T esters for T replacement treatments is analyzed in depth, and the main problems derived from their application are discussed.
Characterising SRD5A2 Gene Variants in 37 Indonesian Patients with 5-Alpha-Reductase Type 2 Deficiency
- 2019
Medicine
It was clearly showed that individuals who were homozygous or compound heterozygous for any of the harmful mutations were more likely to exhibit classic 5ARD2 phenotypes, lower EMS, female assignment at birth, and virilisation during puberty.
Four novel mutations identification in 17 beta-hydroxysteroid dehydrogenase-3 deficiency and our clinical experience: possible benefits of early treatment
- 2023
Medicine
This study provides insights into the clinical aspects of 17β-HSD3 deficiency, emphasizing the vital significance of early intervention in addressing genital appearance concerns.
The Administration of Epididymis Extract Increased the Testosterone Concentration without Affects the Dihydrotestosterone Concentration in Local Male Goat
- 2018
Agricultural and Food Sciences
The result showed that the average concentration of testosterone on K0, KP1, KP2, KP3, and KP 4 in testis respectively were 10.00±2.64 ng/ml; 7.66±7.57 ng/ ML; 5.33±0.73 ng/ML; 2.00+1.00 ng/ ml and 3.00 ± 0.75 ng/l, respectively.
Androgens in pregnancy: roles in parturition
- 2014
Medicine, Biology
The increase in androgen levels throughout gestation is likely to be important for establishment and maintenance of pregnancy and initiation of parturition and further investigation of the underlying mechanisms of androgen action on cervical remodelling and myometrial contractility is needed.
190 References
Role of testosterone and dihydrotestosterone in spontaneous gynecomastia of adolescents.
- 1992
Medicine
Whether spontaneous gynecomastia might exist in an enzimatic blockade of 5 alpha-reductase and whether a decrease in the T:DHT ratio might favor the estrogen action for the progression of breast enlargement deserve further analysis.
Androgen conjugates: physiology and clinical significance.
- 1993
Medicine
Serum levels of testosterone, androstenedione, and dehydroepiandrosterone sulfate (DHEAS) have been used as markers of overproduction of androgens or their precursors and are often elevated in hirsute women, but it has been more difficult to find markers of skin sensitivity to androgens.
Is there a case for DHEA replacement?
- 1998
Medicine
Dihydrotestosterone and testosterone throughout the life span of Czech men.
- 2008
Medicine
The data show that after a peak of DHT:T in infancy and a subsequent decrease in puberty, the ratio of both androgens remains practically without change from 20 years of age till old age.
Lack of defects in androgen production in children with hypospadias.
- 2004
Medicine, Biology
Routine abnormalities in the androgen biosynthetic pathway are an unlikely cause of any degree of hypospadias in boys without accompanying cryptorchidism or genital malformations.
Androgens and male physiology the syndrome of 5alpha-reductase-2 deficiency.
- 2002
Medicine
The clinical, biochemical and molecular genetic analyses of 5alpha-reductase-2 deficiency highlight the significance of DHT in male sexual differentiation and male pathophysiology.
Biochemical endocrinology of the hypogonadal male
- 2010
Biology, Medicine
Measurement of testosterone (T) is crucial to the diagnosis of hypogonadism and the technologies continue to develop, with recent major advances.





