Clinical benefits of low serum digoxin concentrations in heart failure.

@article{Adams2002ClinicalBO,
  title={Clinical benefits of low serum digoxin concentrations in heart failure.},
  author={Kirkwood F. Adams and Mihai Gheorghiade and Barry F Uretsky and James H. Patterson and Todd A. Schwartz and James B. De Young},
  journal={Journal of the American College of Cardiology},
  year={2002},
  volume={39 6},
  pages={946-53}
}
OBJECTIVES We sought to determine whether there was a relationship between serum digoxin concentration (SDC), including SDCs typically regarded as low, and clinical efficacy related to digoxin in patients with symptomatic left ventricular dysfunction. BACKGROUND Digitalis glycosides have been used for 200 years in the treatment of heart failure (HF), but the SDC required for optimal clinical efficacy and acceptable toxicity remains controversial. METHODS This relationship was investigated… CONTINUE READING

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