Clinical benefit of a precision medicine based approach for guiding treatment of refractory cancers

@inproceedings{Radovich2016ClinicalBO,
  title={Clinical benefit of a precision medicine based approach for guiding treatment of refractory cancers},
  author={Milan Radovich and Patrick J. Kiel and Stacy M. Nance and Erin E. Niland and Megan E. Parsley and Meagan E. Ferguson and Guanglong Jiang and Natraj Reddy Ammakkanavar and Lawrence Henry Einhorn and Liang Cheng and Mehdi Nassiri and Darrell D. Davidson and Daniel A. Rushing and Patrick J. Loehrer and Roberto Pili and Nasser Hanna and J. Thomas Callaghan and Todd C. Skaar and Paul R. Helft and Safi Shahda and Bert H. O’Neil and Bryan P. Schneider},
  booktitle={Oncotarget},
  year={2016}
}
PATIENTS AND METHODS Patients with metastatic solid tumors who had progressed on at least one line of standard of care therapy were referred to the Indiana University Health Precision Genomics Program. Tumor samples were submitted for DNA & RNA next-generation sequencing, fluorescence in situ hybridization, and immunohistochemistry for actionable targets. A multi-disciplinary tumor board reviewed all results. For each patient, the ratio of progression-free survival (PFS) of the genomically… CONTINUE READING
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