Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly: St John's wort, garlic oil, Panax ginseng and Ginkgo biloba.

@article{Gurley2005ClinicalAO,
  title={Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly: St John's wort, garlic oil, Panax ginseng and Ginkgo biloba.},
  author={Bill Gurley and Stephanie F Gardner and Martha A Hubbard and Diarria Williams and William Brooks Gentry and Yanyan Cui and Catharina Y W Ang},
  journal={Drugs & aging},
  year={2005},
  volume={22 6},
  pages={
          525-39
        }
}
OBJECTIVES Elderly patients are more likely to ingest prescription medications concurrently with botanical supplements, and may therefore be vulnerable to herb-drug interactions. Phytochemical-mediated modulation of cytochrome P450 (CYP) activity may underlie many herb-drug interactions. Some evidence suggests that CYP activity may decrease in the elderly. If so, herb-mediated changes in CYP activity may take on greater clinical relevance in this population. In this study, single timepoint… CONTINUE READING

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