Clinical assessment of drug-induced QT prolongation in association with heart rate changes.

@article{Extramiana2005ClinicalAO,
  title={Clinical assessment of drug-induced QT prolongation in association with heart rate changes.},
  author={Fabrice Extramiana and Pierre Maison-Blanche and M J Cabanis and Catherine Ortemann-Renon and Philippe Beaufils and Antoine Leenhardt},
  journal={Clinical pharmacology and therapeutics},
  year={2005},
  volume={77 4},
  pages={
          247-58
        }
}
BACKGROUND The formulas for heart rate (HR) correction of QT interval have been shown to overcorrect or undercorrect this interval with changes in HR. A Holter-monitoring method avoiding the need for any correction formulas is proposed as a means to assess drug-induced QT interval changes. METHODS A thorough QT study included 2 single doses of the alpha1-adrenergic receptor blocker alfuzosin, placebo, and a QT-positive control arm (moxifloxacin) in 48 healthy subjects. Bazett, Fridericia… CONTINUE READING

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