Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and Echinacea.

@article{Gurley2008ClinicalAO,
  title={Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and Echinacea.},
  author={Bill Gurley and Ashley Swain and Martha A. Hubbard and Diarria Williams and Gary W. Barone and Faith Hartsfield and Yudong Tong and Danielle Julie Carrier and Shreekar Cheboyina and Sunil Kumar Battu},
  journal={Molecular nutrition & food research},
  year={2008},
  volume={52 7},
  pages={
          755-63
        }
}
Cytochrome P450 2D6 (CYP2D6), an important CYP isoform with regard to drug-drug interactions, accounts for the metabolism of approximately 30% of all medications. To date, few studies have assessed the effects of botanical supplementation on human CYP2D6 activity in vivo. Six botanical extracts were evaluated in three separate studies (two extracts per study), each incorporating 16 healthy volunteers (eight females). Subjects were randomized to receive a standardized botanical extract for 14… CONTINUE READING
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