Clinical aspects of urea cycle dysfunction and altered brain energy metabolism on modulation of glutamate receptors and transporters in acute and chronic hyperammonemia.

@article{Natesan2016ClinicalAO,
  title={Clinical aspects of urea cycle dysfunction and altered brain energy metabolism on modulation of glutamate receptors and transporters in acute and chronic hyperammonemia.},
  author={Vijayakumar Natesan and Renuka Mani and Ramakrishnan Arumugam},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={2016},
  volume={81},
  pages={
          192-202
        }
}
In living organisms, nitrogen arise primarily as ammonia (NH3) and ammonium (NH4(+)), which is a main component of the nucleic acid pool and proteins. Although nitrogen is essential for growth and maintenance in animals, but when the nitrogenous compounds exceeds the normal range which can quickly lead to toxicity and death. Urea cycle is the common pathway for the disposal of excess nitrogen through urea biosynthesis. Hyperammonemia is a consistent finding in many neurological disorders… Expand
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