Clinical aspects of coenzyme Q10: an update

  title={Clinical aspects of coenzyme Q10: an update},
  author={Gian Paolo Littarru and Luca Tiano},
  journal={Current Opinion in Clinical Nutrition and Metabolic Care},
  • G. Littarru, Luca Tiano
  • Published 1 November 2005
  • Medicine, Biology
  • Current Opinion in Clinical Nutrition and Metabolic Care
Purpose of reviewCoenzyme Q10 is administered for an ever-widening range of disorders, therefore it is timely to illustrate the latest findings with special emphasis on areas in which this therapeutic approach is completely new. These findings also give further insight into the biochemical mechanisms underlying clinical involvement of coenzyme Q10. Recent findingsCardiovascular properties of coenzyme Q10 have been further addressed, namely regarding myocardial protection during cardiac surgery… 

Clinical aspects of coenzyme Q10: an update.

Clinical applications of coenzyme Q10.

Recent data indicate that CoQ10 affects expression of genes involved in human cell signalling, metabolism and transport and some of the effects of CoQ20 supplementation may be due to this property, which may provide a significant symptomatic benefit.

An update of Coenzyme Q10 implications in male infertility: Biochemical and therapeutic aspects

The relative distribution of the quinone between these two compartments was studied in infertile men, and the reduction state of CoQ10 in seminal fluid was also investigated.

Ubiquinol Effects on Antiphospholipid Syndrome Prothrombotic Profile: A Randomized, Placebo-Controlled Trial

The results highlight the potential of Qred to modulate the overexpression of inflammatory and thrombotic risk markers in APS and suggest it might act as safe adjunct to standard therapies in APs.

Coenzyme Q10 in Male Infertility

This chapter deals with the role of coenzyme Q10 in male infertility in the light of the increasing evidence of oxidative damage and antioxidant defence in sperm cells and seminal plasma and presents the physiopathological basis linking coen enzyme Q10 and its therapeutical properties.

Evaluate the Effect of Coenzymeq 10 Supplementation on Reducing Oxidative Stress in Patients with Relapsing Remitting Multiple Sclerosis

It is suggested that CoQ10 supplements at a dose of 200 mg/day for 24weeks is safe and can decrease oxidative stress and increase antioxidant enzyme activity in patients with RRMS.



Coenzyme Q 10 Improves Lactic Acidosis, Strokelike Episodes, and Epilepsy in a Patient With MELAS (Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Strokelike episodes)

Efficacy of this therapy in this patient is correlated to control of lactic acidosis and serum creatine kinase levels, and the unpredictable a priori efficacy of therapy suggests that a long-term trial of oral coenzyme Q may be warranted.

Antioxidant treatment of patients with Friedreich ataxia: four-year follow-up.

This therapy resulted in sustained improvement in mitochondrial energy synthesis that was associated with a slowing of the progression of certain clinical features and a significant improvement in cardiac function.

Isolated mitochondrial myopathy associated with muscle coenzyme Q10 deficiency.

The complete recovery of myopathy with exogenous CoQ(10) supplementation observed in this patient highlights the importance of early identification and treatment of this genetic disorder.

Long‐term coenzyme Q10 therapy for a mitochondrial encephalomyopathy with cytochrome c oxidase deficiency

The results indicate that CoQ has clinical value in the long-term management of patients with mitochondrial encephalomyopathies, even though there are clinical limitations to the effects of this therapy.

Coenzyme Q10 Combined With Mild Hypothermia After Cardiac Arrest: A Preliminary Study

Combining CoQ10 with mild hypothermia immediately after CPR appears to improve survival and may improve neurological outcome in survivors, and coenzyme Q10 has shown a protective effect in neurodegenerative disorders.